Evidence map›Paper›PMID 40310102›Full record

ArticlemSphere2025

Adaptation of the tetracycline-repressible system for modulating the expression of essential genes in

Ci Fu, Nicole Robbins, Leah E Cowen

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ci FuDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4811-9062
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5797-0110

Funding

Targeting Hsp90 in cryptococcal fungal pathogenesisR01AI165466 · NIAID · UNIVERSITY OF TORONTO · PI Lauren Elaine Brown, LEAH Elizabeth Cowen · 2022 to 2026
$3.2M
CIHR FDN-154288NIAID NIH HHS R01 AI165466NIH HHS R01AI165466
6 · The paper itself

Abstract

The opportunistic human fungal pathogen

Indexed as

Cryptococcus neoformansGene Expression Regulation, FungalGenes, EssentialTetracyclineAntifungal AgentsFungal ProteinsHSP90 Heat-Shock ProteinsPromoter Regions, GeneticAntifungal AgentsFungal ProteinsHSP90 Heat-Shock ProteinsTetracyclineCryptococcus neoformansessential geneFks1fungal pathogengenetic resourceHsp90tetracycline-repressible system

Identifiers

PMID40310102
PMCPMC12108051

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.