Evidence mapPaperPMID 40310144Full record

ReviewChildren (Basel, Switzerland)2025

Unraveling Metabolic Syndrome in Youth: The Obesity Epidemic's Hidden Complication.

Dana-Teodora Anton-Păduraru, Dana Elena Mindru, Raluca Stefania Stănescu, Felicia Trofin, Claudiu Cobuz, Maricela Cobuz, Lucia Maria Sur, Antoneta Petroaie, Ana Maria Slănină, Mihaela Manole and 2 more

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Early signs of nephropathy in adolescents with obesity.International journal of obesity (2005) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dana-Teodora Anton-PăduraruDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0001-8657-378X
Dana Elena MindruDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Raluca Stefania StănescuDepartment of Morpho-Functional Sciences II, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0008-5800-0894
Felicia TrofinMicrobiology-Department of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-8551-3053
Claudiu CobuzDepartment of Biomedical Sciences, Faculty of Medicine and Biological Sciences, "Stefan cel Mare" University, 720229 Suceava, Romania.
Maricela Cobuz"Sfântul Ioan cel Nou" Emergency County Clinical Hospital, 720224 Suceava, Romania.
Lucia Maria SurDepartment of Child and Mother, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.ORCID 0000-0002-8846-2685
Antoneta PetroaieFamily Medicine-Department of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Ana Maria SlăninăFamily Medicine-Department of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Mihaela ManoleFamily Medicine-Department of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Ana Simona BocecDepartment of Mother and Child Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Adriana CosmescuFamily Medicine-Department of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesOne of the metabolic complications of obesity is known as Metabolic Syndrome (MetS). This narrative review aims to synthesize current research on MetS in young populations, identify knowledge gaps, and guide future studies and funding priorities. It provides evidence-based insights into screening, diagnosis, and treatment, offering practical guidance for healthcare professionals.

methodsA comprehensive search of the literature was conducted to identify relevant studies on obesity in MetS in PubMed and Google Academic electronic database. The search was performed using a combination of "obesity", "complications", "metabolic syndrome", "children", and "adolescents" keywords. Studies were selected based on predefined inclusion and exclusion criteria to ensure relevance and methodological rigor.

resultsThe lack of universally accepted diagnostic criteria for MetS in children has led to inconsistencies in its definition across medical literature. Irrespective of the chosen diagnostic approach, the prevalence of MetS in children and adolescents has exhibited a concurrent rise with the increasing rates of obesity in this age group. The pathophysiology of MetS remains incompletely understood, with ongoing discussions on the interplay of genetic, epigenetic, environmental, dietary, and lifestyle factors. Screening for MetS is recommended for overweight and obese children.

conclusionsEstablishing global, consensus-driven criteria that account for ethnicity, gender, and age would enhance diagnostic accuracy and treatment approaches. The prevention of excessive weight among children and adolescents stands as a paramount objective within modern society's healthcare system. Considering the complexity of the disease and the treatment, the team must be multidisciplinary.

Indexed as

adolescentschildrencomplicationsmetabolic syndromeobesity

Identifiers

PMID40310144
PMCPMC12026447

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.