Evidence map›Paper›PMID 40310487›Full record

ArticleGeroScience2025

The effect of enhanced glycolysis on cardiac aging.

Anna Faakye, Kylene M Harold, Satoshi Matsuzaki, Atul Pranay, Maria F Mendez Garcia, Brooke L Loveland, Sandra N Rigsby, Frederick F Peelor, Craig Eyster, Benjamin F Miller and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna FaakyeAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Kylene M HaroldAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Satoshi MatsuzakiAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Atul PranayAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Maria F Mendez GarciaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Brooke L LovelandAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Sandra N RigsbyAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Frederick F PeelorAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Craig EysterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Benjamin F MillerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Timothy M GriffinAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Michael KinterAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Ying Ann ChiaoAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA.
Kenneth M HumphriesAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 N.E. 13 th Street, Oklahoma City, OK, USA. Kenneth-Humphries@omrf.org.ORCID 0000-0002-6167-3175

Funding

Viral sensor IFIH1 promotes SLE through an altered interferon programP20GM139763 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 2022 to 2025
$12.5M
Proteomics CoreP20GM103447 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$4.2M
IDeA National Resource for Quantitative ProteomicsR24GM137786 · UNIV OF ARKANSAS FOR MED SCIS · 2025 to 2025
$2.1M
Research Development CoreP30AG050911 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$1.3M
Increasing glycolysis in the diabetic heart is cardioprotective and improves glucose toleranceR01HL160955 · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 2025 to 2025
$437k
Impacts of Phosphofructokinase-2 on Cardiac Electrophysiology and Function in DiabetesF31HL176095 · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2025 to 2025
$38k
BLRD VA I01 BX005592NHLBI NIH HHS F31 HL176095NHLBI NIH HHS R01 HL160955NHLBI NIH HHS R01HL160955NIA NIH HHS P30 AG050911NIA NIH HHS P30AG050911NIGMS NIH HHS P20 GM103447NIGMS NIH HHS P20GM103447NIGMS NIH HHS P20 GM139763NIGMS NIH HHS P20GM139763NIGMS NIH HHS R24 GM137786NIGMS NIH HHS R24GM137786U.S. Department of Veterans Affairs VA I01 BX005592
6 · The paper itself

Abstract

Cardiac aging is associated with metabolic changes, including an increased reliance on glycolysis, and an increased susceptibility to cardiovascular diseases. This study explores the relationship between enhanced cardiac glycolysis and aging using the Glyco

Indexed as

AgingGlycolysisHeartMyocardiumAnimalsEnergy MetabolismFemaleMaleMiceMice, Inbred C57BLMitochondria, HeartOxidative StressCardiac agingGlycolysisMitochondriaOxidative stressProteostasis

Identifiers

PMID40310487
PMCPMC12634992

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.