Trial reportEuropean journal of nutrition2025
Effects of vitamin D supplementation on acute respiratory tract infections in 6-8-year-old children: a randomized clinical trial.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03956732 (Effects of Milk Protein and Vitamin D on Children's Growth and Health), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Milk Protein and Vitamin D on Children's Growth and Health (D-pro)
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVitamin D supplementation during winter may protect children from acute respiratory tract infections (ARTI), especially at Northern latitudes where dermal vitamin D synthesis is negligible. This study aimed to investigate our hypothesis that vitamin D supplementation would have beneficial effects on ARTI in children during extended winter.
methodsThis study includes secondary analyses from a double-blinded, randomized, clinical 24-week trial, which investigated effects of vitamin D supplementation and normal vs. high dairy protein intake on children's growth and health. Baseline visits were conducted in Copenhagen, Denmark (55⁰N) from August-October 2019 and endpoint visits February-April 2020. Parents completed illness questionnaires at baseline and every 4 weeks during the intervention. In total, 200 healthy, white 6-8-y-old children were included and randomized to 20 µg/d vitamin D
resultsParents of 189 children (100 females (53%); mean (SD) age, 7.7(0.8) years) completed all ARTI questionnaires. Baseline serum 25-hydroxyvitamin D was 79.8(17.2) nmol/L, which increased by 9.4(17.0) nmol/L in the vitamin D group and decreased by 32.7(17.4) nmol/L in the placebo group. The vitamin D-supplemented children had 17% fewer sick days due to ARTI (risk ratio (RR), 0.83; 95% CI, 0.76-0.90; P < 0.001) compared with placebo. Children also had 43% fewer days with ARTI with fever (RR, 0.57; 95% CI, 0.48-0.67; P < 0.001), vitamin D group compared with placebo. No differences were found in any of the other outcomes.
conclusionVitamin D supplementation reduced the number of days with ARTI. This supports a recommendation of vitamin D supplementation during extended winter at northern latitudes.
trial registrationName: Effects of Milk Protein and Vitamin D on Children's Growth and Health (D-pro). Number: NCT03956732. Link: https://clinicaltrials.gov/study/NCT03956732 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.