Evidence map›Paper›PMID 40312111›Full record

ArticleBMJ open ophthalmology2025

Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity.

Yuhang Yang, Lijun Dong, Hui Qi, Yinsheng Zhang, Yulin Zhang, Jie Sun, Xiaoyan Chai, Xiaofeng Lu, Zixin Fan, Dongting Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuhang YangThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0001-9046-1561
Lijun DongShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Hui QiShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Yinsheng ZhangSchool of Management and E-Business, Zhejiang Gongshang University, Hangzhou, Zhejiang, China.
Yulin ZhangJinan University, Guangzhou, Guangdong, China.ORCID 0000-0003-1828-1077
Jie SunShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.ORCID 0009-0009-4423-7855
Xiaoyan ChaiShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Xiaofeng LuShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Zixin FanShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Dongting WuThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China.
Guoming Zhang *Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Hetian Lei *Department of Ophthalmology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China leihetian18@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRetinopathy of prematurity (ROP) is one of the leading causes of babies' visual impairment and blindness. There is no effective prevention and treatment of ROP so far, and the shared genetic and developmental similarities among the brain, kidneys and retina may offer novel potential therapeutic approaches to ROP.

objectivesThe aim of this study is to explore a correlation of ROP patients and the renal, eye tissue of the mouse model of oxygen-induced retinopathy (OIR). METHODS AND ANALYSIS: We used renal and vitreous untargeted/targeted metabolomics in OIR to conduct our study. Network association analysis and machine learning were performed with the above results and previous studies: retinal-targeted metabolomics of OIR and human blood-targeted metabolomics of ROP.

resultsOIR results in retinal neovascularisation and renal injury. Nine canonical signalling pathways were enriched, which are involved in the initiation and progression of pathologic retinal neovascularisation. Arginine biosynthesis emerged as a common pathway across renal, vitreous, retinal and blood metabolomics, suggesting its potential as a predictive biomarker and therapeutic target for ROP and neonatal kidney injury.

conclusionThe presence of renal injury-related indicators may assist in diagnosing retinal neovascular diseases such as ROP. Arginine biosynthesis is the best common pathway of kidney-untargeted OIR metabolomics, vitreous- and retina-targeted OIR metabolomics and blood-targeted metabolomics of ROP, indicating that arginine biosynthesis might be the common pathway of ROP and neonatal kidney injury.

Indexed as

KidneyRetinaRetinal NeovascularizationRetinopathy of PrematurityVitreous BodyAnimalsAnimals, NewbornBiomarkersDisease Models, AnimalHumansInfant, NewbornMetabolomicsMiceMice, Inbred C57BLOxygenBiomarkersOxygenExperimental & animal modelsNeovascularisationRetina

Identifiers

PMID40312111
PMCPMC12049964

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.