ArticleBMC pediatrics2025
Subtypes of tic disorders in children and adolescents: based on clinical characteristics.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Multimodal brain imaging neurotransmitter marker study of TD: a review of TCM effect mechanisms and precise diagnosis and treatment combining traditional Chinese and western medicine.American journal of translational research · 2026Review
- Identifying Distinct Tourette Disorder Subtypes using Clinical Data.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundTic disorder (TD) is a diverse neurodevelopmental disorder with various symptoms and comorbidities. Traditional classifications based on age onset and duration fail to adequately characterize the full clinical features of TD. This study aims to redefine TD subtypes by a comprehensive analysis of clinical features and comorbidities.
methodsWe assessed 139 children and adolescents aged 6-18 years using 14 scales covering 43 dimensions. The k-means clustering algorithm was used to identify distinct TD subtypes. Differences between these subtypes were analyzed using t-tests and network analysis, with high expected influence (EI) metric representing key symptoms within each subtype.
resultsWe identified two distinct subtypes of TD, with 21.6% of participants classified as subtype1 and 78.4% as subtype2. Subtype1 exhibited more severe symptoms across TD, obsessive-compulsive spectrum disorders, and attention deficit hyperactivity disorder assessments compared to subtype2, with significant differences observed in 81.4% of the scale features. Network analysis revealed differences in core symptoms between the two subtypes; subtype1 primarily involved hyperactivity and vital activities, whereas subtype2 primarily involved attention deficit, hyperactivity and conduct. Furthermore, comparisons with DSM-5 classifications revealed distinct patterns, indicating the novel nature of the identified subtypes.
conclusionOur study identified two novel TD subtypes, highlighting its heterogeneity. Subtype 1 had more severe attention deficits and impulsivity, requiring comprehensive treatment, while subtype 2 had milder symptoms, focusing on support and monitoring. These findings provide insights into TD classification and may help refine treatment strategies. However, the cross-sectional design limits causal interpretations, and reliance on parent-reported data may introduce bias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.