Evidence map›Paper›PMID 40312330›Full record

ArticleBMC cancer2025

Organ-specific cancer biomarker identification: a ten-year single-center study in southern China.

Zhenglin Chang, Bingsen Chen, Suilin Wang, Kaipai Chen, Linliang Huang, Yi Yang, Haojie Wu, Wenhua Jian, Zhangkai J Cheng, Xiujing Han and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhenglin Chang *Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Bingsen Chen *Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Suilin Wang *Department of Orthopedics, Guangzhou Orthopedic Hospital, Guangzhou, 510045, Guangdong Province, China.
Kaipai Chen *Department of Stomatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China.
Linliang HuangDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Yi YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Haojie WuDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
Wenhua JianState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China. 13632268067@163.com.
Zhangkai J ChengDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China. jasontable@gmail.com.
Xiujing HanDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China. hanxiujing@sina.com.
Baoqing SunDepartment of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China. sunbaoqing@vip.163.com.

Funding

Guangzhou Municipal Science and Technology Bureau 202201020426
6 · The paper itself

Abstract

Cancer biomarker discovery is essential for early detection and monitoring, yet there is a lack of comprehensive studies examining organ-specific biomarkers across various cancer types. In this study, we analyzed clinical data from 59,184 cancer patients diagnosed between 2013 and 2023, focusing on 11 major cancer systems. We used propensity score matching with 55,010 healthy controls to create balanced comparison groups. Serum biomarker profiles were assessed through principal component analysis, differential expression analysis, and ROC curve analysis. Our findings revealed organ-specific biomarker patterns, such as decreased CA724, ferritin, and β2-microglobulin in thoracic cancer, reduced serum phosphorus in neurological cancer, and elevated cystatin C and creatinine in urinary system cancer. Further analysis across 22 cancer types uncovered additional biomarkers, including elevated ALT in hepatobiliary cancer, altered coagulation factors in laryngeal cancer, increased monocytes in pancreatic cancer, and reduced complement C3 in intestinal cancer. These results provide valuable insights into the unique biomarker signatures for different cancers, contributing to the potential development of more targeted and efficient screening methods.

Indexed as

Biomarkers, TumorNeoplasmsAdultAgedCase-Control StudiesChinaEarly Detection of CancerFemaleHumansMaleMiddle AgedOrgan SpecificityROC CurveBiomarkers, TumorBiomarker discoveryClinical laboratory testingOrgan-specific cancer biomarkersPan-cancer analysis

Identifiers

PMID40312330
PMCPMC12044899

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.