Evidence map›Paper›PMID 40312757›Full record

ArticleBMC nutrition2025

The relationship between amino acid intake patterns and both general and central obesity.

Fahimeh Alijani, Ali Ahmadi, Nakisa Mohammadpour, Shima Jazayeri, Jamileh Abolghasemi, Hossein Shahinfar, Atie Sadat Khorasanian, Shahnaz Rimaz

Abstract read
In one paragraph

Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fahimeh AlijaniDepartment of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Ali AhmadiModeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Nakisa MohammadpourDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Shima JazayeriDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Jamileh AbolghasemiDepartment of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Hossein ShahinfarNutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Atie Sadat KhorasanianDepartment of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Shahnaz RimazRadiation Biology Research Center, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. rimaz.sh@iums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a threat to public health. Dietary protein and certain amino acids (AAs) have been associated with obesity; however, the association of AAs patterns with excess body weight has not been considered, yet. We aimed to examine the relationship between patterns of AA intake and obesity.

methodsThis cross-sectional study was conducted on 3197 individuals aged 35 to 70 years. Sociodemographic, medical, physical activity, and anthropometric data were collected. Energy and AAs intake were obtained by food frequency questionnaire (FFQ). Factor analysis was utilized to determine the AA patterns. Using multiple logistic regression analysis, the odds ratio (OR) of obesity was calculated among individuals categorized into tertiles of the AAs patterns.

resultsIn this study, three AA patterns were identified. The aromatic pattern consists of phenylalanine, tryptophan, proline, glutamic acid, cysteine, serine, and leucine. Five essential AAs plus tyrosine, aspartic acid, arginine, and glycine were the components of the mixed pattern, and finally, the alanine pattern with high loadings for alanine and histidine was the third one. After adjusting for confounders, individuals in the highest tertile (T3) of the aromatic pattern had lower odds of central obesity compared to those in the lowest tertile (T1) (OR = 0.72, 95% CI: 0.58-0.89; p = 0.003), whereas this association was not observed in the alanine pattern. On the contrary, general obesity showed a positive association in T3 of the alanine pattern in comparison with T1 (OR = 1.65, 95% CI: 1.02-2.67; p = 0.039). Mixed pattern was not associated with any of the obesity types.

conclusionsThe aromatic pattern intake may have an inverse association with central obesity, and following the alanine pattern my contribute to higher odds of general obesity. However, the elaborate relationship between AAs and adiposity warrants further investigation.

Indexed as

Amino acidFactor analysisObesityPatternProtein

Identifiers

PMID40312757
PMCPMC12044820

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.