Evidence map›Paper›PMID 40312850›Full record

ArticleMagnetic resonance in medicine2025

3D virtual biopsy of in vivo pH and metabolism using PRESS and semi-LASER MRS of hyperpolarized

Wolfgang Gottwald, Luca Nagel, Martin Grashei, Sebastian Bauer, Nadine Setzer, Florian Gaksch, Sandra Sühnel, Jason G Skinner, Rickmer Braren, Irina Heid and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wolfgang GottwaldDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID https://orcid.org/0009-0002-3779-7087
Luca NagelDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-5530-6264
Martin GrasheiDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-5019-9359
Sebastian BauerDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Nadine SetzerDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Florian GakschDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Sandra SühnelDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Jason G SkinnerDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Rickmer BrarenInstitute of Diagnostic and Interventional Radiology, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Irina HeidInstitute of Diagnostic and Interventional Radiology, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Geoffrey J ToppingDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Franz SchillingDepartment of Nuclear Medicine, TUM School of Medicine and Health, TUM University Hospital, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-5239-4628

Funding

Bundesministerium für Bildung und Forschung 13N16450/QuE-MRTDFG (Deutsche Forschungsgemeinschaft), German Research Foundation 391523415European Union 820374
6 · The paper itself

Abstract

purposeTo develop and evaluate sequences for multi-voxel magnetic resonance spectroscopy using hyperpolarized molecules.

methodsA standard single voxel PRESS sequence was extended to acquire multiple voxels consecutively. Its SNR was compared against a 2D FID-CSI with both

resultsMulti-voxel PRESS and semi-LASER detected

conclusionFor the first time, we show hyperpolarized MRS using multi-voxel PRESS and semi-LASER sequences for hyperpolarized

Indexed as

Carcinoma, Pancreatic DuctalImaging, Three-DimensionalPancreatic NeoplasmsAnimalsBiopsyCarbon IsotopesHydrogen-Ion ConcentrationKidneyLasersMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicePhantoms, ImagingPyruvic AcidSignal-To-Noise RatioCarbon-13Carbon IsotopesPyruvic Acid13C hyperpolarizationMR‐spectroscopypHpyruvatesemi‐LASER

Identifiers

PMID40312850
PMCPMC12202722

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.