Evidence map›Paper›PMID 40312970›Full record

ArticleObesity (Silver Spring, Md.)2025

Genetic and environmental contributions to the associations between midlife personality and late-life metabolic health.

Colin D Freilich, Jacob J Kunkel, Keely A Dugan, Elise J Vomacka, Adolfo G Cuevas, Kristian Markon, Matt McGue, Glenn I Roisman, Robert F Krueger

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Colin D FreilichDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-6183-7520
Jacob J KunkelInstitute of Child Development, University of Minnesota, Minneapolis, Minnesota, USA.
Keely A DuganDepartment of Psychological Sciences, University of Missouri, Columbia, Missouri, USA.
Elise J VomackaDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Adolfo G CuevasCenter for Anti-Racism, Social Justice, and Public Health, Department of Social and Behavioral Sciences, New York University, New York, New York, USA.
Kristian MarkonDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Glenn I RoismanInstitute of Child Development, University of Minnesota, Minneapolis, Minnesota, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

The impact of adverse interpersonal experiences (AIE) on mild cognitive impairment (MCI) and risk for Alzheimer's disease and related dementias (ADRD) in ethnically diverse twinsR01AG053217 · NIA · UNIVERSITY OF MINNESOTA · PI Robert F Krueger, Glenn I Roisman · 2016 to 2026
$9.1M
Training in genetic and neurobehavioral mechanisms of addictionT32DA050560 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Scott Ian Vrieze · 2020 to 2026
$2.0M
NIA NIH HHS R01 AG053217NIA NIH HHS R01-AG053217NIDA NIH HHS T32 DA050560NIDA NIH HHS T32DA050560
6 · The paper itself

Abstract

objectivePersonality traits such as conscientiousness and emotional stability are consistently linked with better metabolic health, but there is limited evidence on the etiology of these associations and their robustness across the life-span.

methodsTherefore, we estimated phenotypic, genetic, and unique environmental associations of traits indexed by the Multidimensional Personality Questionnaire in early-to-middle adulthood (mean age = 38.3 years) with BMI, waist circumference, high-density lipoprotein cholesterol, C-reactive protein, triglycerides, and glycated hemoglobin in older adulthood (mean age = 70.4 years) using the Minnesota Twin Registry sample (n = 950).

resultsTraits that indexed emotional instability in midlife, such as alienation and stress reactivity, were significant predictors of several metabolic outcomes late in life (bivariate |r| ≤ 0.22), whereas negative associations with traits related to conscientiousness (e.g., control, constraint, achievement) tended to be more modest. For most traits that were phenotypically associated, we observed significant genetic correlations. Additionally, alienation and stress reactivity had weak-to-moderate unique environmental correlations with BMI, waist circumference, and C-reactive protein (r

conclusionsThese results are consistent with an etiology of declining metabolic health into old age involving the propensity toward negative affective experiences decades prior, further validating the health relevance of individual differences in personality.

Indexed as

Gene-Environment InteractionPersonalityAdultAgedBody Mass IndexCholesterol, HDLC-Reactive ProteinFemaleGlycated HemoglobinHumansMaleMiddle AgedMinnesotaPhenotypeSurveys and QuestionnairesTriglyceridesCholesterol, HDLC-Reactive ProteinGlycated HemoglobinTriglycerides

Identifiers

PMID40312970
PMCPMC12353325

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.