Evidence map›Paper›PMID 40313358›Full record

ReviewFrontiers in transplantation2025

Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models.

Douglas J Anderson, Jayme E Locke

Abstract readReview
In one paragraph

Review in Frontiers in transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Douglas J AndersonDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Jayme E LockeNYU Langone Health, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the xenograft in a human decedent or non-human primate. Additionally, we will discuss the pharmacologic agents typically employed in each model, highlighting both the ability of the decedent model to test clinically-relevant medication strategies that may be impossible in non-human primates due to species-specificity.

Indexed as

decedent modelkidneynon-human primatepharmacokineticsrenal physiologyxenotransplant

Identifiers

PMID40313358
PMCPMC12043684

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.