ArticleFrontiers in public health2025
Polypharmacy, drug-drug interactions, and potentially inappropriate medications among older adults: a cross-sectional study in Northeast Ethiopia.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Screening for Potential Drug-Drug Interactions in Patients Receiving Anticoagulant Therapy: A Comparison of Three Drug Interaction Databases for Consistency in Severity Rating, Evidence Classification, and Clinical Management.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Electrocardiographic Abnormalities in Elderly Patients Receiving Psychotropic Therapy in the Emergency Department: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- Potentially inappropriate medication use and associated factors among older adults in Ethiopia: a systematic review and meta-analysis.Journal of pharmaceutical policy and practice · 2025Review
- Risk prediction model for severe potential drug-drug interactions in colorectal cancer patients: a real-world data study.Frontiers in pharmacology · 2025Article
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4 authors.
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Abstract
Background: The global older adult population is expected to increase from 524 million in 2010 to 1.5 billion by 2050, mainly in developing countries. Age-related diseases, comorbidities, and polypharmacy make appropriate prescribing crucial. This study aimed to assess the prevalence of polypharmacy, drug-drug interaction, and potentially inappropriate medication use and its factors in an Ethiopian hospital. Methods: A facility-based cross-sectional study on 236 patients aged 65 and above at Dessie Comprehensive Specialized Hospital (Jan 2022-Apr 2023) used the 2023 Beers Criteria and START/STOP V.3 to identify potentially inappropriate medications. Polypharmacy and potential drug-drug interactions were assessed using Micromedex®, with descriptive statistics and binary logistic regression performed in SPSS version 26. Result: Of the 236 patients in this study, 94 (39.8, 95% CI: 35.7-44.5%) were prescribed at least one potentially inappropriate medication per the STOPP/START criteria, with 81 (34.3%) identified by STOPP and 13 (5.5%) by START. According to the Beers Criteria, 108 patients (45.7, 95% CI: 40.1-51.0%) received at least one potentially inappropriate medication. Polypharmacy was observed in 80 patients (33.9, 95% CI: 29.1-38.5%), and potential drug-drug interactions were identified in 111 patients (47.0%). Being female (AOR: 2.93), age ≥75 (AOR: 1.52), and polypharmacy (AOR: 3.20) were linked to potentially inappropriate medication use per Beers Criteria. Age 70-74 (AOR: 2.30) and polypharmacy (AOR: 3.10) were also associated per STOPP/START criteria. Conclusion: Polypharmacy, drug-drug interactions, and potentially inappropriate medications are common among older Ethiopian patients, with age, sex, and polypharmacy as contributing factors. Future studies are needed to assess the health and economic impacts of potentially inappropriate medications use.
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