ReviewFrontiers in pharmacology2025
Advances in plant essential oils and drug delivery systems for skincare.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating efficacy, safety, and innovation in skin care applications of essential oils: a systematic review.Frontiers in medicine · 2025Pooled it
- Thymoquinone-Loaded Electrospun Fibrous Mats as Advanced Wound Dressing Materials.Pharmaceutics · 2026Article
- From Agri-Food Byproducts to High-Value Bioactive Compounds: A Critical Review Linking Green Recovery and Chemical Profiling to Circular Valorization.Molecules (Basel, Switzerland) · 2026Review
- Development of perilla essential oil-based nanoemulsions as anti-psoriatic and dermal delivery platforms for topical therapy.International journal of pharmaceutics: X · 2026Article
- Decoding the antiviral potential of eugenol, thymol and vanillin against human cytomegalovirus infection.The Journal of general virology · 2026Article
- Prolonged Antimicrobial Effects ofInternational journal of microbiology · 2026Article
- Action Mechanism of Essential Oils or Their Components Against Pathogenic Bacteria: Literature Review.International journal of microbiology · 2026Review
- Valorization of Thyme Combined with Phytocannabinoids as Anti-Inflammatory Agents for Skin Diseases.Pharmaceutics · 2025Article
- New Antimicrobial Gels Based on Clove Essential Oil-Cyclodextrin Complex and Plant Extracts for Topical Use.Gels (Basel, Switzerland) · 2025Article
- Liposomal Delivery of a BiotechnologicalAntioxidants (Basel, Switzerland) · 2025Article
- Chemical Composition, Anti-Tyrosinase and Antioxidant Potential of Essential Oils fromMolecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects to preserve mummies, ancient Greeks used olive oil for sun protection, and ancient Chinese used essential oils to treat wounds. When essential oils are applied to the facial skin, their potent anti-inflammatory, antioxidant, and antibacterial pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, and anti-aging effects. Purpose: This paper aims to summarize the application of plant essential oil in skin whitening, anti-inflammatory, antioxidant and antibacterial in recent years, and deeply analyzes the internal relationship between essential oil and modern drug delivery system, expounds how to overcome the limitations of essential oil through specific drug delivery system, to enhance its biological activity and stability, realize sustained release and reduce its potential toxicity, and also discusses the positive effects of essential oil on brain function through olfactory pathway, emphasizes the possible safety risks in the use of essential oil, and puts forward corresponding suggestions for use. Methods: Using keywords such as "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects and anti-inflammatory," "anti-anxiety," and "drug carrier delivery systems," a comprehensive search was conducted in the PubMed, CNKI, Baidu, and Wanfang databases to summarize articles from the past 5 years. Further screening was performed to select studies demonstrating the efficacy of essential oils through topical or external application. Results: Various essential oils showed their efficacy as strong oxidants, antibacterial agents, anti-inflammatory agents, and skin-whitening agents. Combined with a new drug delivery system, it not only enhances the biological activity of essential oil but also reduces the inherent defects of essential oil, such as volatility, irritation, and toxicity, and has a targeted delivery effect. At the same time, the integration of essential oil into skin care products can make use of the dual functions of smell and the epidermal system to nourish and repair the skin and maximize the pharmacological effects of essential oil. Conclusion: This review delves into the application of essential oils and delivery systems, advocating for a broader integration of natural plant resources with modern technology. By strategically utilizing essential oils, we can promote the sustainable development of the global economy. However, extensive clinical trials are still required to evaluate the effectiveness and safety of essential oil delivery systems.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.