Evidence map›Paper›PMID 40313749›Full record

ArticleResearch square2025

Bridging Gaps in Antibody Responses and Animal Welfare: Assessing Blood Collection Methods and Vaginal Immunity in Mice Immunized with Intranasal Gonococcal Vaccines.

Abhishek Chanda, Yujuan Song, Junaid Nazir, Chenwei Lin, Alicia Cheng, Jennifer Sargent, Aleksandra E Sikora

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Abhishek ChandaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97330, United States.
Yujuan SongDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97330, United States.
Junaid NazirDepartment of Clinical Biochemistry, Lovely Professional University, Phagwara Punjab, India.
Chenwei LinProteomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, United States.
Alicia ChengDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97330, United States.
Jennifer SargentCarlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97330, United States.
Aleksandra E SikoraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97330, United States.

Funding

Proteomics-Driven Reverse Vaccinology for GonorrheaR01AI117235 · NIAID · OREGON STATE UNIVERSITY · PI Aleksandra Elzbieta Sikora · 2015 to 2026
$6.7M
NIAID NIH HHS R01 AI117235
6 · The paper itself

Abstract

Assessing antibody titers and functional responses is essential for evaluating vaccine efficacy, yet the impact of blood collection methods on these immunological assessments remains unclear. Retro-orbital (RO) blood collection is commonly used but significant complications can occur. Increasingly, investigators have adopted alternative blood collection approaches, such as saphenous vein (SV) sampling to improve laboratory animal welfare. This study compared RO and SV sampling in the development of a

Indexed as

ACPELISAepitope predictionfunctional blocking antibodiesgonorrheaimmunoblottinglysozyme activitymice immunizationMtrENeisseria gonorrhoeaeretroorbital bleedingsaphenous vein blood collectionserum bactericidal assay

Identifiers

PMID40313749
PMCPMC12045373

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.