Evidence map›Paper›PMID 40314172›Full record

ArticlePsychological medicine2025

Associations of childhood adversity and substance use disorder polygenic scores with disorder severity and diagnostic criteria.

Jackson F SooHoo, Christal N Davis, Angela Han, Zeal Jinwala, Joel Gelernter, Richard Feinn, Henry R Kranzler

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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jackson F SooHooCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Christal N DavisCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Angela HanCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Zeal JinwalaCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Richard FeinnDepartment of Medical Sciences, Frank H. Netter School of Medicine, Quinnipiac University, North Haven, CT, USA.
Henry R KranzlerCenter for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450

Funding

Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
BLRD VA I01 BX004820NIAAA NIH HHS AA030056NIAAA NIH HHS R01 AA030056
6 · The paper itself

Abstract

backgroundGenetic and environmental factors, including adverse childhood experiences (ACEs), contribute to substance use disorders (SUDs). However, the interactions between these factors are poorly understood.

methodsWe examined associations between SUD polygenic scores (PGSs), ACEs, and the initiation of use and severity of alcohol (AUD), opioid use disorder (OUD), and cannabis use disorder (CanUD) in 10,275 individuals (43.5% female, 47.2% African-like ancestry [AFR], and 52.8% European-like ancestry [EUR]). ACEs and SUD severity were modeled as latent factors. We conducted logistic and linear regressions within ancestry groups to examine the associations of ACEs, PGS, and their interaction with substance use initiation and SUD severity.

resultsAll three SUD PGS were associated with ACEs in EUR individuals, indicating a gene-environment correlation. Among EUR individuals, only the CanUD PGS was associated with initiating use, whereas ACEs were associated with initiating use of all three substances in both ancestry groups. Additionally, a negative gene-by-environment interaction was identified for opioid initiation in EUR individuals. ACEs were associated with all three SUD severity latent factors in EUR individuals and with AUD and CanUD severity in AFR individuals. PGS were associated with AUD severity in both ancestry groups and with CanUD severity in AFR individuals. Gene-by-environment interactions were identified for AUD and CanUD severity among EUR individuals.

conclusionsFindings highlight the roles of ACEs and polygenic risk in substance use initiation and SUD severity. Gene-by-environment interactions implicate ACEs as moderators of genetic susceptibility, reinforcing the importance of considering both genetic and environmental influences on SUD risk.

Indexed as

Adverse Childhood ExperiencesAlcoholismGene-Environment InteractionMarijuana AbuseMultifactorial InheritanceOpioid-Related DisordersSubstance-Related DisordersAdolescentAdultBlack or African AmericanFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedSeverity of Illness IndexChildhood adversitydiagnostic criteriagene-environment interactionpolygenic scoressubstance use disorders

Identifiers

PMID40314172
PMCPMC12094658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.