ReviewMolecular biology reports2025
Role of oxidative stress in intervertebral disc degeneration: mechanisms, pathogenesis, and therapeutic strategies.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Design and evaluation of peroxiredoxin 1 agonist based on scaffold hopping of salvianolic acids and combinatorial click chemistry.Acta pharmacologica Sinica · 2026Article
- Drug-Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90-RBX1 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual-functional hydrogel platform suppresses M1 activation and stabilizes M2 macrophages in intervertebral disc degeneration.Materials today. Bio · 2026Article
- Rebuilding the degenerative disc microenvironment: mesenchymal stem cells, exosomes, and bioengineered scaffolds.Frontiers in bioengineering and biotechnology · 2026Review
- The Biomechanical Landscape of Lumbar Disc Herniation: Mechanobiological Insights Into Injury and Regeneration.Neurospine · 2026Review
- Antioxidant biomaterials in intervertebral disc regeneration: current status and future clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Mechanobiology of intervertebral disc degeneration: From pathological mechanisms to therapeutic approaches.Mechanobiology in medicine · 2025Review
- ACE-mediated Glycosylation Stabilizes PSAP To Promote GPR37-dependent Macrophage-Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The onset inflammatory parameters and the Cobb angle in adolescent idiopathic scoliosis: a case-control study.Croatian medical journal · 2025Article
- Tie2-mediated CBL ubiquitination of EGFR underlies ultrasound-responsive silk fibroin/graphene oxide hydrogel-troxerutin therapy for intervertebral disc degeneration.Materials today. Bio · 2025Article
- Innovative strategies in combating intervertebral disc degeneration: pathological mechanisms and biomaterial advancements.Frontiers in bioengineering and biotechnology · 2025Review
- Redox-associated gene and microRNA signatures in degenerative intervertebral disc disease.Molecular painArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intervertebral disc degeneration (IDD) is a prevalent and debilitating spinal condition, characterised by the progressive degradation of disc structure and function, often accompanied by pain. Despite our increasing understanding of IDD, the precise mechanisms underlying its development and potential therapeutic targets remain incompletely understood. Recent research has highlighted that oxidative stress, along with immune abnormalities, mechanical loading imbalances, and metabolic disruptions, play a pivotal role in IDD initiation and progression. Oxidative stress in IDD results from an overproduction of reactive oxygen species (ROS) and a compromised ability to eliminate them, disrupting the redox homeostasis within the intervertebral disc. This disturbance in redox balance leads to extracellular matrix degradation (ECM), induces cellular apoptosis, and worsens the damage to disc tissues. This review provides a comprehensive overview of the pathophysiological processes of IDD, with a particular focus on the role of oxidative stress. Additionally, we explore current advancements in therapeutic strategies targeting oxidative stress, including antioxidant drugs, biomaterials, and stem cell-based approaches, offering promising avenues for the management and treatment of IDD.
Indexed as
Identifiers
40314795What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.