SynthesisGeroScience2026
Depression increases cancer mortality by 23-83%: a meta-analysis of 65 studies across five major cancer types.
Synthesis in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Symptom management in cancer care: An evolutionary concept analysis for a digitally enabled collaborative framework.Asia-Pacific journal of oncology nursing · 2026Review
- Artificial intelligence in oncology: empowering clinicians for responsible integration.ESMO real world data and digital oncology · 2026Review
- Depression remodels tumor microenvironment to drive tumor progression: Bio-behavioural signalling pathways and clinical interventions.Journal of advanced research · 2026Review
- Health-Related Quality of Life in Lung Cancer Survivors: Sociodemographic, Clinical, and Psychosocial Modulators.Current oncology (Toronto, Ont.) · 2026Article
- The global cancer mental health survey: insights from patient and provider experiences on psychosocial care access.EClinicalMedicine · 2026Article
- Integrative omics identify NID2 as a therapeutic target linking depression and colorectal cancer in humans.iScience · 2026Article
- Psychometric properties of the Patient Health Questionnaire-9 and the Generalized Anxiety Disorder-7 in Mexican cancer patients.Palliative & supportive care · 2026Article
- Article
- Long-term risk of depression in lung, colon, breast, and prostate cancer: a 25-year nationwide comparative study.BMC cancer · 2026Article
- Article
- Impact of Depression and/or Anxiety on Mortality in Women with Gynecologic Cancers: A Nationwide Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Chronic Psychological Stress in Oncogenesis: Multisystem Crosstalk and Multimodal Interventions.Research (Washington, D.C.) · 2025Review
- How Does Subjective Social Status Associate With Depression Among the Labor Force Population in China? - Analysis of the Mediation Effect Based on the Sense of Social Equity.International journal of public health · 2025Article
- How mindfulness and coping styles shape anxiety and depression in metastatic gastrointestinal cancer.Frontiers in psychology · 2025Article
- Role of depression-mediated alterations in pro-inflammatory cytokines in carcinogenesis.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a prevalent but often underrecognized comorbidity among cancer patients. Emerging evidence suggests that psychological distress may adversely impact cancer outcomes, but the magnitude of its effect on survival remains unclear. This meta-analysis evaluates the association between depression diagnosed after cancer diagnosis and cancer-specific and all-cause mortality across major cancer types. A systematic search of PubMed, Web of Science, Google Scholar, and the Cochrane Library was conducted to identify cohort studies examining the impact of depression on cancer mortality. Studies were included if they assessed clinically diagnosed depression or depressive symptoms using validated scales and reported hazard ratios (HRs) for mortality outcomes. A random-effects meta-analysis was performed to pool HR estimates, with heterogeneity assessed via Cochran's Q and I
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.