Evidence map›Paper›PMID 40314874›Full record

ReviewDiscover oncology2025

Mushroom-derived bioactive compounds pharmacological properties and cancer targeting: a holistic assessment.

Sakshi Zade, Tarun Kumar Upadhyay, Safia Obaidur Rab, Amit Baran Sharangi, Sorabh Lakhanpal, Nadiyah M Alabdallah, Mohd Saeed

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Diversity and environmental drivers ofOpen life sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sakshi ZadeDepartment of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, 391760, Gujarat, India.
Tarun Kumar UpadhyayDepartment of Biotechnology, Parul Institute of Applied Sciences and Research and Development Cell, Parul University, Vadodara, 391760, Gujarat, India. tarun_bioinfo@yahoo.co.in.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
Amit Baran SharangiDepartment of Plantation, Spices, Medicinal and Aromatic Crops, Faculty of Horticulture, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, 741252, West Bengal, India.
Sorabh LakhanpalSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144401, India.
Nadiyah M AlabdallahDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441, Dammam, Saudi Arabia.
Mohd SaeedDepartment of Biology, College of Science, University of Hail, Hail, Saudi Arabia.

Funding

King Khalid University, Abha, Saudi Arabia R.G.P.2/509/45
6 · The paper itself

Abstract

Worldwide, cancer is a great cause of death and a public health issue. Cancer has been the leading cause of death in developing nations for many years. Cancers are typically treated with surgery, immunotherapy, chemotherapy, and radiation therapies. However, these techniques have some undesirable side effects, including neurological illness, high toxicity levels, discomfort, and mental stress. Biologically active compounds discovered in mushrooms may be utilized to reduce ill effects and increase the efficacy of the current therapies. Mushrooms have efficient therapeutic activities such as antimicrobial, antitumor, antidiabetic, anticancer, and antioxidant activity. Bioactive compounds like polysaccharides, terpenoids, β-glucan, steroids, polyphenols, flavonoids, proteins, and peptides have precisely well-recognized anticancer activity. In this review paper, we described the biomedical activities of the mushroom against various cancers. The immune-modulating components in mushrooms activate NK cells and macrophages to target cancer cells. Due to immunomodulatory properties of mushroom-derived bioactive compounds in cancer therapy to highlight the need for further research in this area further studies needs to validate in clinical samples.

Indexed as

AntioxidantAnti-tumorBioactive compoundsCancerMushrooms

Identifiers

PMID40314874
PMCPMC12048390

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.