Evidence map›Paper›PMID 40315313›Full record

ArticleScience advances2025

Heterologous synthesis of a simplified nitrogenase analog in

Yiling A Liu, Chi Chung Lee, Kamil Górecki, Martin T Stiebritz, Calder Duffin, Joseph B Solomon, Markus W Ribbe, Yilin Hu

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Minimal ATP-Independent NAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiling A LiuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0003-4154-2888
Chi Chung LeeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0002-5266-6686
Kamil GóreckiDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0002-9672-2408
Martin T StiebritzDepartment of Biology, Friedrich-Alexander University Erlangen-Nuremberg, D-91052 Erlangen, Germany.ORCID 0000-0001-8024-4352
Calder DuffinDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0002-1861-9878
Joseph B SolomonDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Markus W RibbeDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0002-7366-1526
Yilin HuDepartment of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.ORCID 0000-0002-9088-2865

Funding

Nitrogenase Assembly MechanismR01GM067626 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI RIBBE, MARKUS W · 2003 to 2024
$6.3M
Probing a novel reaction mechanism of nitrogenase with dynamic active-site rearrangementsR01GM141046 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HU, YILIN · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM067626NIGMS NIH HHS R01 GM141046
6 · The paper itself

Abstract

The heterologous synthesis of a nitrogen-fixing system in a non-diazotrophic organism is a long-sought-after goal because of the crucial importance of nitrogenase for agronomy, energy, and the environment. Here, we report the heterologous synthesis of a two-component nitrogenase analog from

Indexed as

Escherichia coliNitrogenaseAzotobacter vinelandiiBacterial ProteinsNitrogen FixationOxidoreductasesBacterial ProteinsNitrogenaseOxidoreductases

Identifiers

PMID40315313
PMCPMC12047441

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.