Trial reportAnnals of the American Thoracic Society2025
Endothelial Glycocalyx Degradation in Sepsis: Analysis of the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) Trial, a Multicenter, Phase 3, Randomized Trial.
Abstract readRandomized Controlled TrialMulticenter StudyClinical Trial, Phase III
In one paragraph
Trial report in Annals of the American Thoracic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis.The Journal of clinical investigation · 2026Trial
- The Effects of Conservative Fluid Management and Active Deresuscitation on Markers of Tissue Perfusion, Kidney Injury, and Vascular Injury in Critically Ill Adults: A Secondary Analysis of the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) Trial.Critical care explorations · 2026Trial
- The endothelium response to kidney injury.Nature reviews. Nephrology · 2026Review
- Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model.Intensive care medicine experimental · 2026Article
- Vascular permeability and loss of glycocalix in sepsis: the role of fluid resuscitation.Intensive care medicine · 2026Article
- Angiopoietin-2 Surpasses Soluble Thrombomodulin and Syndecan-1 in Characterizing Septic Shock and Predicting Mortality--A Prospective Observational Study.Journal of inflammation research · 2026Article
- Endothelial Glycocalyx Integrity as a Prognostic Key in Sepsis: New Insights from the CLOVERS Trial.Annals of the American Thoracic Society · 2025Article
- Finding the Four-Leaf CLOVERS: Biologic Subphenotypes and Fluid Tolerance in Sepsis.American journal of respiratory and critical care medicine · 2025Article
- Global Research Trends in Sepsis-Associated Coagulopathy: A Web of Science-Based Bibliometric Analysis (2000-2024).Journal of multidisciplinary healthcare · 2025Review
- Interaction between endothelial injury and immune response in septic shock: from basic research to clinical applications.Frontiers in physiology · 2025Review
Corrections and comments
- Commented on by
Authors and funding
17 authors.
Kaori OshimaDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Chiara Di GravioDepartment of Biostatistics.
Bailu YanDepartment of Biostatistics.
Sarah A McMurtryDepartment of Medicine and.
Ryan BurkeDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Lisa M LevoirDepartment of Biostatistics.
Max S KravitzDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Daniel StephensonDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, Colorado.
Aaron IssaianDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, Colorado.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, Colorado.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado, Aurora, Colorado.
Ivor S DouglasDepartment of Medicine and.
Wesley H SelfVanderbilt Institute for Clinical and Translational Research, and.
Christopher J LindsellDepartment of Biostatistics and Bioinformatics and the Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
Jonathan S SchildcroutDepartment of Biostatistics.
Eric P SchmidtDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Funding
CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL NetworkU01HL123009 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, THOMPSON, BOYD TAYLOR · 2014 to 2021
$67.2MOutcome Dependent Sampling Studies of Longitudinal Data: Design and AnalysisR01HL094786 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jonathan Scott Schildcrout · 2009 to 2026
$6.1MClinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123022 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAPIRO, NATHAN I, TALMOR, DANIEL STUART · 2014 to 2020
$2.9MPrevention and Early Treatment of Acute Lung InjuryU01HL123004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2014 to 2020
$2.6MClinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123031 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYZY, ROBERT C, PARK, PAULINE K · 2014 to 2020
$2.6MEnhancing the Surrogate Informed Consent Process for Critical Care ResearchU01HL123010 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GINDE, ADIT A., MOSS, MARC · 2014 to 2020
$2.6MPrevention and Early Treatment of Acute Lung Injury Clinical Trials NetworkU01HL123033 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICE, TODD W · 2014 to 2020
$2.4MPreventive and Early Treatment of Acute Lung Injury Clinical Trials Network- Pgh - SupplementU01HL123020 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C, YEALY, DONALD M · 2014 to 2020
$2.4MLong Term Outcomes and Macrophage Biology in Patients with EVALIU01HL123018 · NHLBI · IHC HEALTH SERVICES, INC. · PI BLEDSOE, JOSEPH R, BROWN, SAMUEL MORRIS · 2014 to 2020
$2.4MPacific Northwest Clinical Center for the NHLBI PETAL NetworkU01HL123008 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, ROBINSON, BRYCE · 2014 to 2020
$2.3MAcute Lung Injury Group New England Program to Support PETAL Network ResearchU01HL122989 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI STEINGRUB, JAY S · 2014 to 2020
$2.2MEinstein PETAL: Clinical Center for the PETAL NetworkU01HL122998 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GONG, MICHELLE NG, RICHARDSON, LYNNE D. · 2014 to 2020
$1.9MNHLBI NIH HHS HL149422NHLBI NIH HHS R01 HL094786NHLBI NIH HHS R01 HL149422NHLBI NIH HHS U01 HL122989NHLBI NIH HHS U01 HL122998NHLBI NIH HHS U01 HL123004NHLBI NIH HHS U01 HL123008NHLBI NIH HHS U01 HL123009NHLBI NIH HHS U01 HL123010NHLBI NIH HHS U01 HL123018NHLBI NIH HHS U01 HL123020NHLBI NIH HHS U01 HL123022NHLBI NIH HHS U01 HL123023NHLBI NIH HHS U01 HL123027NHLBI NIH HHS U01 HL123031NHLBI NIH HHS U01 HL123033
Abstract
PubMed holds no abstract for this paper.
Indexed as
Endothelium, VascularFluid TherapyGlycocalyxResuscitationSepsisVasoconstrictor AgentsAgedCrystalloid SolutionsFemaleHeparan SulfateHumansMaleMiddle AgedSyndecan-1Crystalloid SolutionsHeparan SulfateSDC1 protein, humanSyndecan-1Vasoconstrictor Agentsendothelial glycocalyxfluid resuscitationsepsis mortality
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.