Evidence map›Paper›PMID 40316158›Full record

ArticleClinical immunology (Orlando, Fla.)2025

Incidence and risk factors for CMV and EBV infection in infants with low T-cell receptor excision circles on newborn screen.

Megan E Day-Lewis, Laura Berbert, Michele DeGrazia, Christina Yee, Ari J Fried, Alan A Nguyen, Jaime E Hale, Anne Counihan, Anne Marie Comeau, Elsa R Treffeisen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Megan E Day-LewisDivision of Immunology, Boston Children's Hospital, Boston, MA, USA. Electronic address: Megan.Day-Lewis@childrens.harvard.edu.
Laura BerbertInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, USA.
Michele DeGraziaCardiovascular and Critical Care Services, Boston Children's Hospital, Boston, MA, USA; Division of Neonatology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Christina YeeDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Ari J FriedDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Alan A NguyenDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Jaime E HaleNew England Newborn Screening Program, ForHealth Consulting, UMass Chan Medical School, Worcester, MA, USA.
Anne CounihanNew England Newborn Screening Program, ForHealth Consulting, UMass Chan Medical School, Worcester, MA, USA.
Anne Marie ComeauNew England Newborn Screening Program, ForHealth Consulting, UMass Chan Medical School, Worcester, MA, USA; Department of Pediatrics, T.H. Chan School of Medicine, Worcester, MA, USA.
Elsa R TreffeisenDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Mary Poyner ReedMedicine Patient Services, Boston Children's Hospital, Boston, MA, USA.
Craig D PlattDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Janet ChouDivision of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

Funding

MOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1M
NIAID NIH HHS T32 AI007512
6 · The paper itself

Abstract

backgroundNewborn screening for severe combined immunodeficiency (SCID) using T cell receptor excision circles (TRECs) identifies patients with other causes of lymphopenia. The risk of opportunistic infection in patients with non-SCID lymphopenia is poorly understood. We aim to describe incidence and risk factors associated with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection in patients with low TRECs.

methodsThis retrospective study analyzed 289 patients with ≥1 abnormal TREC result.

resultsNineteen patients had CMV or EBV detected by PCR. Most had resolution of infection (n = 13). Two have chronic viremia, and four expired due to disseminated CMV. Risk factors included undetectable TRECs, consanguinity, family history, low NK, naïve CD4, naïve CD8 cells, and phytohemagglutinin.

conclusionInfection with CMV and EBV in patients with low TRECs is rare, however some may benefit from preventative measures. Consideration of risk factors may aid in decision-making and improve outcomes.

Indexed as

Cytomegalovirus InfectionsEpstein-Barr Virus InfectionsReceptors, Antigen, T-CellSevere Combined ImmunodeficiencyCytomegalovirusFemaleHerpesvirus 4, HumanHumansIncidenceInfantInfant, NewbornMaleNeonatal ScreeningRetrospective StudiesRisk FactorsReceptors, Antigen, T-CellCytomegalovirusEpstein-Barr virusLymphopeniaNewborn screeningSevere combined immunodeficiencyT cell receptor excision circle

Identifiers

PMID40316158
PMCPMC12393798

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.