Evidence map›Paper›PMID 40316173›Full record

SynthesisJournal of gynecology obstetrics and human reproduction2025

Risk factors for postoperative complications following hysterectomy in endometrial cancer patients: A systematic review.

Yara K Habo, Nora K Habo, Ahmed Adham R Elsayed, Marc D Basson

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of gynecology obstetrics and human reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07462663 (SHAPE-ENDO), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07462663 phase4not yet recruitingstarted 2027, after this paper: background citation

SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate Surgery Versus a Multimodal Metabolic Optimization and Prehabilitation Strategy Before Surgery in Patients With Atypical Endometrial Hyperplasia or Low-Risk Endometrioid Endometrial Cancer and BMI ≥40 kg/m²

Ran2027Enrolled80Registered outcomes34Posted comparisons0ConditionsAtypical Endometrial Hyperplasia, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, BMI>40, Endometrial CancerArmsDietetic-Nutritional intervention, Endometrial Biopsy With or Without Hysteroscopy, GLP-1 receptor agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
PMID 33755728PMID 33667417PMID 36216945PMID 33397713PMID 40768192PMID 40744042PMID 39429275PMID 38764577PMID 36326317PMID 35314087PMID 34238643PMID 30193337other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yara K HaboCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Nora K HaboCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Ahmed Adham R ElsayedCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA; Department of Surgery, Northeast Ohio Medical University, Rootstown, OH 44272, USA; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Marc D BassonCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA; Department of Surgery, Northeast Ohio Medical University, Rootstown, OH 44272, USA; Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address: mbasson@neomed.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndometrial cancer is the most prevalent type of cancer of the female reproductive system. Certain risk factors have been linked to a range of severe postoperative complications following hysterectomies in this patient population. Therefore, this systematic review aims to encompass all the significant risk factors identified that lead to postoperative complications in endometrial cancer patients following hysterectomy and possible risk factor mitigation strategies that can be made to limit these postoperative complications.

methodsThe authors conducted the search across four libraries, including Cochrane, VHL, Web of Science, and PubMed. The authors identified original studies published from inception till November 2, 2024, that were relevant to the research question and fit the eligibility criteria.

resultsPreoperative factors include cancer staging, diabetes, frailty, obesity, medications, ASA class, and smoking; while intraoperative considerations include blood loss, operative time, length of hospital stay, lymphadenectomy, and surgical complexity. These risk factors were found to lead to a variety of postoperative complications ranging in grades on the Clavien Dindo classification (CD), including surgical site infections, urinary tract infections, lymphedema, lymphorrhea, lymphocyst, wound disruption, wound dehiscence, respiratory issues, ileus, and prolonged hospital stays.

conclusionBefore undergoing hysterectomies, endometrial cancer patients should be screened for risk factors to decrease the risk of postoperative complications. The employment of tailored mitigation strategies for individual patients through preoperative optimization, intraoperative management, and patient counseling is essential in preventing postoperative complications. By improving patient care and reducing hospital-acquired costs, surgeons will be more equipped to handle complex procedures and prevent unwanted outcomes.

Indexed as

Endometrial NeoplasmsHysterectomyPostoperative ComplicationsFemaleHumansRisk FactorsEndometrial cancerHysterectomyPostoperative complicationsRisk factors

Identifiers

PMID40316173

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.