Evidence map›Paper›PMID 40316215›Full record

ArticleThe American journal of pathology2025

Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation.

Evan B Lynch, Neeraj Kapur, Tatiana Goretsky, Emily M Bradford, Hemendra Vekaria, Sarayu Bhogoju, Syed A Hassan, Emily Pauw, Margarita G Avdiushko, Goo Lee and 3 more

Abstract read
In one paragraph

Article in The American journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Evan B LynchDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky; Division of Plastic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky.
Neeraj KapurDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky.
Tatiana GoretskyDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky.
Emily M BradfordDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky.
Hemendra VekariaLexington VA Healthcare System, Lexington, Kentucky; Department of Neuroscience, University of Kentucky, Lexington, Kentucky.
Sarayu BhogojuDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky.
Syed A HassanDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky.
Emily PauwCollege of Medicine, University of Kentucky, Lexington, Kentucky.
Margarita G AvdiushkoDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky.
Goo LeeHeersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Tianyan GaoDepartment of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky.
Patrick G SullivanLexington VA Healthcare System, Lexington, Kentucky; Department of Neuroscience, University of Kentucky, Lexington, Kentucky.
Terrence A BarrettDivision of Digestive Diseases and Nutrition, Department of Medicine, University of Kentucky, Lexington, Kentucky; Lexington VA Healthcare System, Lexington, Kentucky. Electronic address: t.barrett@uky.edu.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
The Role of Crypt Fissioning in IBD Ulcer HealingR01DK095662 · NIDDK · UNIVERSITY OF KENTUCKY · PI BARRETT, TERRENCE A. · 2012 to 2024
$3.9M
CSRD VA I01 CX001353NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIDDK NIH HHS R01 DK095662
6 · The paper itself

Abstract

Intestinal stem cell (ISC) signaling maintains the balance of self-renewal and differentiation. Herein, the role of phosphatidylinositol 3-kinase (PI3K) signaling in ISC responses to radiation was interrogated using Villin-Cre pik3r1

Indexed as

Epithelial CellsIntestinal MucosaPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesSignal TransductionAnimalsHumansMaleMiceStem CellsPhosphatidylinositol 3-KinasePhosphatidylinositol 3-Kinases

Identifiers

PMID40316215
PMCPMC12405924

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.