Evidence map›Paper›PMID 40316517›Full record

ArticleNature communications2025

Sex-specific hypothalamic neural projection activity drives caregiving in mice.

Ilaria Carta, Tushar Arora, Stefano Lutzu, Giovanni Podda, Gaspar Nicolay Vera Ortega, Stephanie Rudolph, Anita E Autry

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ilaria CartaDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-1270-573X
Tushar AroraDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0009-0005-6651-6995
Stefano LutzuDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Giovanni PoddaDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Gaspar Nicolay Vera OrtegaDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0009-0005-7169-2491
Stephanie RudolphDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID http://orcid.org/0000-0003-0388-7762
Anita E AutryDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA. Anita.Autry@einsteinmed.edu.ORCID http://orcid.org/0000-0003-3933-1977

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behaviorR01HD113787 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Anita Autry · 2024 to 2026
$1.5M
Functional Neuroanatomy of Circuits Governing Parental BehaviorR00HD085188 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUTRY, ANITA · 2018 to 2020
$826k
NICHD NIH HHS P50 HD105352NICHD NIH HHS R00 HD085188NICHD NIH HHS R01 HD113787U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R00HD085188U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD113787Whitehall Foundation (Whitehall Foundation, Inc.) Research Award
6 · The paper itself

Abstract

Infant care is critical for survival and healthy development. In laboratory mice, unmated males and females display infant-directed behavior ranging from neglect and aggression to alloparental care. Previous research suggests that excitatory neurons in the perifornical area of the hypothalamus (PeFA) mediate pup-directed aggression. Because medial preoptic area galanin-expressing (MPOA

Indexed as

HypothalamusMaternal BehaviorNeuronsPreoptic AreaAggressionAnimalsBehavior, AnimalFemaleGalaninGroomingMaleMiceMice, Inbred C57BLNeural PathwaysOptogeneticsSex CharacteristicsGalanin

Identifiers

PMID40316517
PMCPMC12048593

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.