ArticleNature communications2025
The CIN-TCP transcription factors regulate endocycle progression and pavement cell size by promoting cell wall pectin degradation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A group of TCP transcription factors is a missing link in strigolactone signaling.Journal of integrative plant biology · 2026Article
- The Methyltransferase CcKmt3 Regulates Cell Wall Degradation Enzymes Activity to Enhance the Infection Process in Cytospora chrysosperma.Molecular plant pathology · 2026Article
- The MsNAC73-MsMPK3 Complex Modulates Salt Tolerance and Shoot Branching of Alfalfa via Activating MsPG2 and MsPAE12 Expressions.Plant biotechnology journal · 2025Article
- Multi-omics analyses reveal regulatory networks underpinning metabolite biosynthesis in Nicotiana tabacum.Nature communications · 2025Article
- Identification and functional evaluation of cyclin-dependent kinase genes reveals that CDKB1;1 and CDKB2;2 contribute to the balance of mitosis and endoreduplication in Medicago truncatula nodule.BMC plant biology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
In plants, endoreplication, the process where nuclear DNA replicates in the absence of mitosis, and remodeling of the primary cell walls are both coupled with cell expansion. However, the mechanisms by which these two processes coordinate to determine cell size remain largely elusive. Here, employing the tcpΔ7 septuple mutant disabling seven of the eight CIN-TCP transcription factors in Arabidopsis, we find that hindered endoreplication progression in tcpΔ7 whereby ploidy increases from 8 C to beyond is correlated with an increase in cell wall pectin. CIN-TCPs transcriptionally activate POLYGALACTURONASE LIKE 1 (PGL1), which encodes a polygalacturonase downregulating both abundance and molecular mass of pectin polymers. Genetic analysis of PGL1 in both the wild type and tcpΔ7 backgrounds confirm that pectin reduction promotes endocycle progression and cell enlargement. Collectively, these findings reveal a critical role of pectin in regulating endoreplication, providing insights in the understanding of cell growth and organ development in plants.
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