Evidence map›Paper›PMID 40316550›Full record

Observational studyScientific reports2025

Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy.

Qian Zhang, Xujie Zhang, Yi Li, Lingwei Zeng, Runyin Zhu, Yan Xin, Lixia Liu, Zhenjie Hu, Yan Huo

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qian ZhangDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China.
Xujie ZhangDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China.
Yi LiDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, China.
Lingwei ZengDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China.
Runyin ZhuDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China.
Yan XinDepartment of Intensive Care Unit, The Third Hospital of Shijiazhuang, Shijiazhuang, China.
Lixia LiuDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China.
Zhenjie HuDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China. 46400533@hebmu.edu.cn.
Yan HuoDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, No. 12 of Jiankang Road, Changan District, Shijiazhuang, 050011, China. huoyan523@hebmu.edu.cn.

Funding

Medical Science Research Project of Hebei 20230158
6 · The paper itself

Abstract

Sepsis-associated encephalopathy (SAE) represents a severe neurological complication in sepsis, characterized by high mortality and cognitive impairment. Although clinical significance, SAE lacks effective diagnostic and prognostic tools. This study evaluates the predictive value of neuron-specific enolase (NSE) and regional cerebral oxygen saturation variability (rSO₂%) as indicators for diagnosing and prognosing SAE. A prospective observational study enrolled 70 sepsis patients, classified into SAE and non-SAE groups. Serum NSE levels and rSO₂% were measured alongside clinical data and 28-day mortality outcomes. NSE and rSO₂% were identified as independent indicators of SAE (P < 0.05). Combined analysis achieved a higher diagnostic accuracy, with an area under the ROC curve of 0.749, compared to single indicators. Kaplan-Meier survival analysis reveals that elevated NSE levels and increased rSO₂% are associated with significantly reduced 28-day survival (P < 0.001). These findings suggest that NSE and rSO₂%are valuable indicators for the diagnosis and prognosticating SAE. Their combined application significantly improves diagnostic efficacy, providing a basis for personalized early intervention strategies.

Indexed as

Oxygen SaturationPhosphopyruvate HydrataseSepsis-Associated EncephalopathyAgedBiomarkersFemaleHumansKaplan-Meier EstimateMaleMiddle AgedOxygenPrognosisProspective StudiesROC CurveSepsisBiomarkersOxygenPhosphopyruvate HydrataseDiagnosisEgional cerebral oxygen saturation variability (rSO₂%)Neuron-specific enolase(NSE)PrognosisRegional cerebral oxygen saturation(rSO₂)Sepsis-associated encephalopathy(SAE)

Identifiers

PMID40316550
PMCPMC12048628

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.