Trial reportNature biotechnology2026
The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson's disease.
Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01898390 (An Open Label Study to Assess the Safety and Efficacy of Neural Allo-Transplantation With Fetal Ventral Mesencephalic Tissue in Patients With Parkinson's Disease), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open Label Study to Assess the Safety and Efficacy of Neural Allo-Transplantation With Fetal Ventral Mesencephalic Tissue in Patients With Parkinson's Disease
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2026Pooled it
- Pooled it
- Human embryonic stem cell-derived dopaminergic cells for Parkinson's disease: a phase 1/2 open-label trial.Nature medicine · 2026Trial
- Stem Cell Therapy for Parkinson's Disease: A Mechanistically Distinct Role for Muse Cells.Journal of clinical medicine · 2026Review
- Review
- Cell-based regenerative interventions in Parkinson's disease: Overcoming pharmacological limitations.Acta pharmaceutica Sinica. B · 2026Review
- A new dawn for Parkinson's disease: commentary on the emergence of stem cell-based therapies.Translational neurodegeneration · 2026Review
- Stem cell treatments and Parkinson's disease: Science and misconceptions.Journal of Parkinson's disease · 2026Review
- Review
- The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: Implications for the STEM-PD clinical trial.Stem cell reports · 2026Article
- Advanced Therapeutics in Parkinson's Disease: What's New?Current neurology and neuroscience reports · 2026Review
- Clinical trial highlights: Dopamine cell-replacement therapies.Journal of Parkinson's disease · 2026Review
- Mesenchymal stromal/stem cells for neurological disorders in humans: an evidence-mapped clinical review.Frontiers in cellular neuroscience · 2026Review
- A trial of fetal cells for Parkinson's disease brings lessons for the field.Nature biotechnology · 2026Article
- Article
- Gut Permeability and Microbiota in Parkinson's Disease: Mechanistic Insights and Experimental Therapeutic Strategies.International journal of molecular sciences · 2025Review
- A new era in regenerative medicine: Cell replacement therapy for Parkinson's disease is on the horizon.Cell stem cell · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors.
Roger A BarkerJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. rab46@cam.ac.uk.ORCID http://orcid.org/0000-0001-8843-7730
Nicholas P Lao-KaimDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID http://orcid.org/0000-0002-0241-7630
Natalie Valle GuzmanJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Dilan AthaudaDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.
Hjalmar BjartmarzDepartment of Neurosurgery, Skånes University Hospital and Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-3944-8139
Anders BjörklundDepartment of Neurology, Skånes University Hospital and Lund University, Lund, Sweden.
Alistair ChurchDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Emma CuttingJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Danielle DaftJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Viswas DayalDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.
Stephen DunnettDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0003-1826-1578
Amy EvansJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Shane GrealishDepartment of Neurology, Skånes University Hospital and Lund University, Lund, Sweden.
Naomi HannawayDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID http://orcid.org/0000-0001-8608-7757
Xiaoling HeJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0009-0004-1002-8418
Sam HewittJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9219-6324
Zinovia KefalopoulouDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.
Philipp MahlknechtDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-0671-0516
Antonio Martín-BastidaDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.ORCID http://orcid.org/0000-0002-8480-7009
Krista FarrellJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Sarah MooreJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Harry BulstrodeJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Tagore NakornchaiJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1573-9812
Jenny Nelander-WahlestedtDepartment of Neurology, Skånes University Hospital and Lund University, Lund, Sweden.
Linnea RoupéDepartment of Neurology, Skånes University Hospital and Lund University, Lund, Sweden.
Gesine PaulDepartment of Neurology, Skånes University Hospital and Lund University, Lund, Sweden.
Kathryn PeallDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Anne RosserDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Adriana Roca-FernándezDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Sophie RowlandsDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Anne-Marie McGorrianDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Caroline ScherfDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Ngoc Nga VinhDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Victoria RobertonDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Claire KellyDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Mariah LelosDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Eduardo TorresDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Kate ShiresDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Rachel HillsDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Debbie WilliamsDivision of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Andreas-Antonios RoussakisDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Krista SibleyDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.
Pamela TyersJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Ruwani WijeyekoonJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Caroline Williams-GrayJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Thomas FoltynieDepartment of Clinical & Movement Neurosciences, UCL Institute of Neurology, London, UK.
Paola PicciniDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, UK.
Robert MorrisJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Stanley E LazicJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Olle LindvallLund Stem Cell Center and Division of Neurology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Malin ParmarDepartment of Neurosurgery, Skånes University Hospital and Lund University, Lund, Sweden.
Hakan WidnerDepartment of Neurosurgery, Skånes University Hospital and Lund University, Lund, Sweden.
TransEuro consortium
Funding
Cure Parkinson's Trust (CPT) RG81537Hjärnfonden (Swedish Brain Foundation) FO2019-0301New York Stem Cell Foundation (NYSCF) NYSCF-R-I37Svenska Forskningsrådet Formas (Swedish Research Council Formas) 2016-00873Svenska Forskningsrådet Formas (Swedish Research Council Formas) 2021-00661Wellcome Trust 223011Wellcome Trust (Wellcome) 203151/A/16/ZWellcome Trust (Wellcome) 203151/Z/16/Z
Abstract
Transplantation of human fetal ventral mesencephalic tissue in individuals with Parkinson's disease has yielded clinical benefits but also side effects, such as graft-induced dyskinesias. The open-label TransEuro trial ( NCT01898390 ) was designed to determine whether this approach could be further developed into a clinically useful treatment. Owing to poor availability of human fetal ventral mesencephalic tissue, only 11 individuals were grafted at two centers using the same tissue preparation protocol but different implantation devices. No overall clinical effect was seen for the primary endpoint 3 years after grafting. No major graft-induced dyskinesias were seen, but we observed differences in outcome related to transplant device and/or site. Mean dopamine uptake improved at 18 months in seven individuals according to [
Indexed as
Fetal Tissue TransplantationMesencephalonParkinson DiseaseAdultAgedDopamineDopaminergic NeuronsFemaleHumansMaleMiddle AgedPositron-Emission TomographyTreatment OutcomeDopamine
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT01898390ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.