SynthesisBMC oral health2025
Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Effectiveness ofFrontiers in immunology · 2026Article
- Probiotic preparations in mitigating chemotherapy-induced oral mucositis: therapeutic efficacy, mechanisms, and clinical translation potential.Frontiers in cellular and infection microbiology · 2026Review
- Immunonutrients for radiation-induced oral mucositis in head and neck cancer: current evidence and future perspectives.Frontiers in immunology · 2026Review
- Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier.Frontiers in immunology · 2026Review
- Cross-disciplinary communication between oral and gut microbiota in head and neck cancer.Frontiers in oncology · 2026Review
- The role of probiotics in controlling oral biofilm formation and mitigating oral squamous-cell carcinoma risk.Archives of microbiology · 2025Review
- Evaluating microbial regulation as a preventive strategy for radiation-related caries: A review.Head & face medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundOral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in the prevention and treatment of oral complications in thyroid and head and neck cancers.
methodsFollowing the PRISMA criteria, a systematic review and meta-analysis of included studies on efficacy, safety, dosage, and duration of treatment was performed.
resultsA total of 12 randomized controlled trials and a total of 885 individuals were included in this meta-analysis. Our analysis showed that biotics had a slight but insignificant effect on the incidence of oral mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), and a significant impact on reducing the severity of oral mucositis (RR = 0.62, 95% CI [0.48, 0.80]). Biotics also had a slight but insignificant effect in developing xerostomia in thyroid and Head and neck cancer (HNC) patients. Subgroup meta-analysis demonstrated that Bifidobacterium-containing products were more effective than other blends.
conclusionOur findings demonstrated that biotics are effective and safe for HNC and thyroid patients suffering from oral complications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.