ArticleBMC public health2025
Top comorbidities in osteoporotic fracture patients in a northeast population in China.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- In Vivo Models of Diabetes: Unravelling Molecular Pathways in Metabolic and Skeletal Complications.Biomedicines · 2026Review
- The therapeutic potential of descending regulatory pathways from brain to bone in osteoporosis: focusing on the brain-bone axis.Frontiers in endocrinology · 2026Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundOsteoporotic fractures frequently occur in conjunction with various diseases, and the comorbidity of fractures is a significant contributor to their high disability and mortality rates. This study aimed to examine the pattern of comorbidity in fracture patients and non-fracture individuals.
methodsUsing data from community- and hospital-based populations in Jilin, China, we identified osteoporotic fracture patients over 40 years of age. We matched each fracture patient with two non-fracture individuals based on age (± 3 years) and sex. Major comorbidities including hypertension, type 2 diabetes, hyperlipidemia, obesity, coronary heart disease (CHD), stroke, hyperthyroidism, hyperparathyroidism, osteoporosis, rheumatoid arthritis, respiratory diseases, gastrointestinal diseases, and breast cancer, were ascrertained from patients' laboratory test results and self-reported data.
resultsWe identified 51 hospital-based fracture patients, 181 community-based fracture patients and 362 matched non-fracture individuals. The mean age for both overall fracture patients and non-fracture individuals was 67.8 years. Females accounted for 72.8% of overall fracture patients and 71.8% of non-fracture individuals. The most common comorbidity was hypertension for overall fracture patients (45.3%), hospital-based fracture patients (39.2%), and non-fracture individuals (56.4%), whereas hyperlipidemia was the most frequent condition for community-based fracture patients (63.6%). The top binary comorbidity combination pattern for community-based fracture patients (30.4%) and non-fracture individuals (29.6%) was hyperlipidemia & hypertension, while for hospital-based (15.7%) and overall (15.1%) fracture patients it was hypertension & type 2 diabetes. The average degree of comorbidity network for overall fracture patients (7.0) was higher than that for non-fracture individuals (5.4).
conclusionsThe most common comorbidities were hyperlipidemia and hypertension among fracture patients. As compared to non-fracture individuals, fracture patients exhibited a more complex comorbidity network. These findings help us better target the management of comorbidities in patients with osteoporotic fractures and reduce the burden associated with fractures.
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