ArticleArtificial organs2025
Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs.
Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From Preservation to Regeneration: Stem Cell-Derived Therapies in Machine-Perfused Kidney Transplants - A Systematic Review and Meta-Analysis.Kidney & blood pressure research · 2026Pooled it
- Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion.Transplantation direct · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundNormothermic Machine Perfusion (NMP) is essential in renal transplantation to improve organ viability before transplantation. This study presents a proof of concept for simultaneous ex situ perfusion of paired porcine kidneys using exogenous creatinine and iohexol clearances to assess renal function, with the primary objective of examining intra-individual differences.
methodsFive kidney pairs (n = 10) were harvested from pigs, preserved at 4°C for 3 h, and subjected to 6-h NMP. Each pair was perfused with a solution containing red blood cells, and perfusion parameters were monitored continuously. Biochemical parameters were assessed using hourly perfusate and urine samples. Kidney function was evaluated using creatinine, which was introduced during the priming procedure.
resultsNo significant differences were observed between paired kidneys in terms of perfusion and biochemical parameters. Both kidneys maintained stable mean arterial pressures (67.40 ± 12.08 mmHg for right vs. 71.50 ± 4.36 mmHg for left) and flows (68.90 ± 38.61 mL/min vs. 54.00 ± 26.08 mL/min), with consistent electrolyte balance and pH levels. The high inter-individual variability in perfusion and biochemical parameters underscores the importance of paired comparisons.
conclusionsThis pig model of simultaneous NMP of paired kidneys demonstrates that the intra-individual variance is low, which makes it possible to test treatments prior to kidney transplantation using one kidney as a valid comparator of the other.
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Registered trials
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