Evidence mapPaperPMID 40319110Full record

ArticleCommunications medicine2025

The expected impact of a cure for HIV among people with HIV and key populations.

Kim A G J Romijnders, Franco Romero Gonzalez, Amy Matser, Myrthe L Verburgh, Maartje Dijkstra, Peter Reiss, Mirjam Kretzschmar, Pythia Nieuwkerk, Maarten Schim van der Loeff, Maartje Basten and 1 more

Abstract read
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kim A G J RomijndersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. k.a.g.romijnders@umcutrecht.nl.ORCID http://orcid.org/0000-0002-1491-3826
Franco Romero GonzalezJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0009-0008-4509-8060
Amy MatserDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.
Myrthe L VerburghAmsterdam Institute for Immunology & Infectious diseases, Amsterdam, the Netherlands.
Maartje DijkstraAmsterdam Institute for Immunology & Infectious diseases, Amsterdam, the Netherlands.
Peter ReissAmsterdam Institute for Immunology & Infectious diseases, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7896-6428
Mirjam KretzschmarJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4394-7697
Pythia NieuwkerkAmsterdam Institute for Immunology & Infectious diseases, Amsterdam, the Netherlands.
Maarten Schim van der LoeffDepartment of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4903-7002
Maartje Basten *Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-9982-7048
Ganna Rozhnova *Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-6725-7359

Funding

Aids Fonds (Dutch Aids Foundation) P-52901
6 · The paper itself

Abstract

backgroundThis study explored the expected impact of two hypothetical HIV cure scenarios on quality of life, sexual satisfaction, and stigma among people with HIV and key populations (i.e., partners and communities of people with HIV and men who have sex with men without HIV) in the Netherlands.

methodsA cross-sectional survey was conducted among people with HIV and key populations from October 2021 until June 2022. We assessed quality of life, sexual satisfaction, and stigma using linear regression and mixed models to compare participants' current situation with two hypothetical HIV cure scenarios: HIV post-intervention control, where HIV is suppressed without the need for ongoing antiretroviral treatment, but the viral reservoir is expected to persist, and HIV elimination, where HIV is completely removed from the body.

resultsOur findings show that people with HIV (n = 222) expect improved quality of life and sexual satisfaction, as well as reduced stigma, compared to their current situation following both post-intervention control and elimination. Key populations (n = 495) similarly expect improvements for both HIV cure scenarios, except no expected improvement was found for quality of life following post-intervention control. Participants aged 18 to 34 anticipate greater improvements from both cure scenarios than those over 34.

conclusionsBoth people with HIV and key populations without HIV expect an HIV cure to have a positive impact on quality of life, sexual satisfaction, and stigma. This impact is expected not only for HIV elimination but also for HIV post-intervention control, the development of which appears more feasible.

Identifiers

PMID40319110
PMCPMC12049444

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.