ArticleNPJ digital medicine2025
Latent retinal structural patterns with aging.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
12 authors.
Funding
Abstract
Optical coherence tomography (OCT) is an efficient tool for non-invasively evaluating retinal structures. Retinal thinning changes assessed using OCT are recognized as potential biomarkers for systemic conditions such as Alzheimer's disease, Parkinson's disease, and chronic kidney disease. However, age-related retinal changes remain largely unexplored, complicating the differentiation between physiological and pathological alterations. Here, we introduced a highly granular approach to assess age-related spatial changes in the inner retina using latent retinal archetypes, identifying 36 retinal archetypes of macula and peripapillary sector images from 189,387 OCTs of 22,494 individuals. Subsequently, we evaluated the associations between these archetypes and age; age-related archetypes are characterized by total or superior thinning in the macula sector. Among individuals with myopia, the inferior thinning pattern in the macula ganglion cell-inner plexiform layer was associated with aging. The age-related effects in the peripapillary sector were primarily reflected in the shape of retinal artery trajectories. Overall, latent retinal archetypes would offer new avenues for the effective utilization of retinal biomarkers in age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.