Evidence mapPaperPMID 40319311Full record

ArticleCardiovascular diabetology2025

Association of obesity- and insulin resistance-related indices with subclinical carotid atherosclerosis in type 1 diabetes: a cross-sectional study.

Dongli Yang, Jie Zhou, Malgorzata A Garstka, Qian Xu, Qiaoyue Li, Li Wang, Lijun Ren, Qiuhe Ji, Tao Liu

Abstract read
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Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongli Yang *Department of Endocrinology and Metabolism, The First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Jie Zhou *Department of Endocrinology and Metabolism, The First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Malgorzata A Garstka *Department of Endocrinology, Core Research Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Qian XuDepartment of Endocrinology and Metabolism, Xi'an International Medical Center Hospital of Northwest University, Xi'an, 710100, Shaanxi, China.
Qiaoyue LiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Li WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Lijun RenDepartment of Endocrinology and Metabolism, Xi'an International Medical Center Hospital of Northwest University, Xi'an, 710100, Shaanxi, China.
Qiuhe JiDepartment of Endocrinology and Metabolism, Xi'an International Medical Center Hospital of Northwest University, Xi'an, 710100, Shaanxi, China. qiuheji@hotmail.com.
Tao LiuDepartment of Endocrinology and Metabolism, Xi'an International Medical Center Hospital of Northwest University, Xi'an, 710100, Shaanxi, China. healthscholar@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity and insulin resistance are well-established risk factors for atherosclerosis and cardiovascular disease (CVD). Although some obesity- and insulin resistance-related indices (OIRIs) have been linked to CVD, their associations with subclinical carotid atherosclerosis (SCA) in individuals with type 1 diabetes (T1D) remain unclear. This study aims to systematically explore and compare the associations of various common OIRIs with SCA in T1D population.

methodsA total of 418 adult inpatients with classic T1D admitted from October 2008 to June 2021 to the First Affiliated Hospital of Air Force Medical University in Xi'an, China were included in this study. Demographic, anthropometric, and laboratory data were collected. Studied OIRIs comprised body mass index, waist-to-height ratio, waist-to-hip ratio (WHR), a body shape index, abdominal volume index, body adiposity index, body roundness index, conicity index, triglyceride-glucose index, visceral adiposity index, Chinese visceral adiposity index (CVAI), lipid accumulation product, estimated glucose disposal rate (eGDR), triglyceride-to-HDL ratio, and cardiometabolic index. Binary logistic regression, restricted cubic spline (RCS), and receiver operating characteristic curves were used to examine the associations of these indices with SCA.

resultsIn multivariable logistic regression analyses, after adjusting for potential confounders, per 1.0-standard deviation (SD) increase in CVAI (OR, 95% CI: 1.68, 1.16-2.47), eGDR

conclusionAmong various OIRIs, CVAI shows the strongest association with SCA in adults with T1D. These findings suggest that CVAI may merit further longitudinal investigation as a potential marker for SCA assessment in this population.

Indexed as

Carotid Artery DiseasesDiabetes Mellitus, Type 1Insulin ResistanceObesityAdiposityAdultAsymptomatic DiseasesBiomarkersBlood GlucoseChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk AssessmentBiomarkersBlood GlucoseChinese visceral adiposity indexInsulin resistanceObesitySubclinical atherosclerosisType 1 diabetes

Identifiers

PMID40319311
PMCPMC12049799

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.