Trial reportAlimentary pharmacology & therapeutics2025
Clinical Trial: Effect of a 28-Day Low FODMAP Diet on Gastrointestinal Symptoms Associated With Endometriosis (EndoFOD)-A Randomised, Controlled Crossover Feeding Study.
Trial report in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Low-FODMAP Diet for Gastrointestinal Symptoms in Endometriosis: A Systematic Review.Nutrients · 2026Pooled it
- An Overview of Essential Nutritional Strategies and Products in the Treatment of Endometriosis.Nutrients · 2025Pooled it
- Effect of Fish-Derived Lipids on Inflammation Status and Health-Related Quality of Life in Women with Endometriosis.Nutrients · 2026Trial
- The Challenges of Performing Controlled Trials of Diet Therapies in Gastroenterology.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- Management of bowel dysfunction after pelvic surgery for endometriosis.International journal of colorectal disease · 2026Review
- The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets.International journal of molecular sciences · 2026Review
- A Roadmap for Advancing Women's Health in Disorders of the Gut-Brain Interaction.United European gastroenterology journal · 2026Review
- Orchestrating the gut microbiota-mitochondrial-immune axis in gynecological diseases: mechanisms and dual-targeting therapeutic strategies.Frontiers in reproductive health · 2026Review
- Nutrition and Endometriosis: Current Evidence on Dietary Risk Factors and Clinical Impact - A Narrative Review.Journal of inflammation research · 2026Review
- From local lesion to multisystem disease: integrated crosstalk among the gut microbiota, immune system, and host metabolism in endometriosis.Frontiers in immunology · 2026Review
- Immune-nutritional interactions in endometriosis: current evidence and future perspectives in disease management.Frontiers in immunology · 2026Review
- Microbiota insights in endometriosis.Microbiome · 2025Review
- Effectiveness of Medical Nutrition Therapy in the Management of Patients with Obesity and Endometriosis: from the Mediterranean Diet To the Ketogenic Diet, Through Supplementation. The Role of the Nutritionist in Clinical Management.Current obesity reports · 2025Review
- Deciphering the Genetic Association Between the FODMAP Diet and Recurring Oral Aphthae-The Mediating Role of Ferroptosis.Food science & nutrition · 2025Article
- The Role of Plant-Based Diets and Personalized Nutrition in Endometriosis Management: A Review.Medicina (Kaunas, Lithuania) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundGastrointestinal symptoms affect most women with endometriosis, but therapeutic interventions are poorly defined.
aimsTo compare the effects of a 28-day low fermentable oligo-, di- and mono-saccharides and polyols (FODMAP) or control diet on gastrointestinal symptom severity in individuals with endometriosis and poorly controlled gastrointestinal symptoms.
methodIn this single-blinded randomised, controlled cross-over feeding trial, we randomised women aged ≥ 18 years to 28 days of either a low FODMAP (< 5 g/day FODMAPs) or control diet (20 g/day FODMAPs), both modelled on Australian Dietary Guidelines, before a ≥ 28-day washout and crossover to the alternate diet. The primary outcome was the proportion of responders defined according to the response in overall gastrointestinal symptoms on a 100-mm visual analogue scale. Secondary outcomes included gastrointestinal symptoms, quality of life and psychological status.
resultsOf 35 women randomised (mean age 31; 95% confidence interval 29, 33 years), 21 (60%) responded to the low FODMAP diet compared with 9 (26%) to the control diet (p = 0.008). In the 4th week of the dietary intervention, overall symptom scores were 35 (21, 42) mm on the low FODMAP diet and 58 (55, 65) mm on the control diet (p < 0.001). Abdominal pain, bloating, stool form and quality of life for both gastrointestinal and endometriosis-associated scales were significantly better for the low FODMAP diet compared with the control diet, but not overall for perceived stress, anxiety or depression.
conclusionsThe low FODMAP diet ameliorates gastrointestinal symptoms related to endometriosis and improves quality of life. Confirmation of these findings in a real-world setting is required.
trial registrationThe trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12621000153819).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.