Evidence map›Paper›PMID 40319507›Full record

ReviewCurrent opinion in cell biology2025

Myosin 2 - A general contractor for the cytoskeleton.

Joseph J Tidei, Patrick W Oakes, Jordan R Beach

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Impact of Zinc on T Cell Motility and the Immunological Synapse.International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph J TideiDept. Cell & Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA.
Patrick W OakesDept. Cell & Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA. Electronic address: poakes@luc.edu.
Jordan R BeachDept. Cell & Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA. Electronic address: jbeach1@luc.edu.

Funding

MECHANISMS OF CONTRACTILE NETWORK ASSEMBLYR35GM138183 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Jordan Beach · 2020 to 2026
$2.8M
Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin DynamicsR35GM137959 · NIGMS · UNIVERSITY OF FLORIDA · PI VITRIOL, ERIC A · 2020 to 2024
$2.3M
Mechanotransduction via LIM Domain Protein MechanosensingR01GM148644 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI Patrick William Oakes · 2023 to 2026
$1.2M
NIGMS NIH HHS R01 GM148644NIGMS NIH HHS R35 GM137959NIGMS NIH HHS R35 GM138183
6 · The paper itself

Abstract

Cells derive their shape, and in turn much of their behavior, from the organization of the cytoskeleton. While a myriad of proteins contribute to the regulation and organization of this dynamic structure, two of the principal components are actin filaments, which provide the structure, and myosin motors, which generate the majority of the forces. Here we review recent results on the assembly and kinetics of non-muscle myosin 2, and highlight how the cellular environment modulates local myosin behavior and signaling.

Indexed as

CytoskeletonMyosin Type IIActin CytoskeletonAnimalsHumansSignal TransductionMyosin Type II

Identifiers

PMID40319507
PMCPMC12151302

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.