ArticleRedox biology2025
Differential inflammation, oxidative stress and cardiovascular damage markers of nano- and micro-particle exposure in mice: Implications for human disease burden.
Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Air quality and health implications of exposure to ultrafine particle pollution.Cardiovascular research · 2026Article
- Ultrafine Particles and Mortality: A Scoping Review of Epidemiologic Evidence and Exposure Assessment Limitations.Toxics · 2026Review
- Quantifying Olfactory and Alveolar Deposition of Ultrafine Particles Using Multiscale Modeling: Implications for Brain Exposure.Environmental science & technology · 2026Article
- The environmental exposome in heart failure risk and progression.Nature reviews. Cardiology · 2026Review
- Changes of Long-Term Exposure to Ultrafine Particles From 2010 to 2019 in High Income Countries in Relation to Cardiovascular Diseases.GeoHealth · 2026Article
- Review
- Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model.Antioxidants (Basel, Switzerland) · 2026Article
- A comprehensive review/expert statement on environmental risk factors of cardiovascular disease.Cardiovascular research · 2025Review
- Site-Specific Microparticle Inhalation Therapy: A New Approach to Nasopharyngeal Symptoms.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Antioxidant Intervention Against Microplastic Hazards.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Particulate matter (PM) poses a significant risk to human health; however, it remains uncertain which size fraction is especially harmful and what mechanisms are involved. We investigated the varying effects of particle size on specific organ systems using a custom mouse exposure system and synthetic PM (SPM). Whole-body exposure of mice showed that micrometer-sized fine SPM (2-4 μm) accumulated in the lungs, the primary entry organ, while nanometer-sized SPM (<250 nm) did not accumulate, suggesting a transition into circulation. Mice exposed to micro-SPM exhibited inflammation and NADPH oxidase-derived oxidative stress in the lungs. In contrast, nano-SPM-exposed mice did not display oxidative stress in the lungs but rather at the brain, heart, and vascular levels, supporting the hypothesis that they penetrate the lungs and reach the circulation. Sources of reactive oxygen species from micro-SPM in the lung are NOX1 and NOX2, driven by pulmonary inflammation, while oxidative stress from nano-SPM in the heart is mediated by protein kinase C-dependent p47
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.