SynthesisMusculoskeletal care2025
Association Between Prescribed Dosage of Resistance Exercise and Change in Pain and Physical Function in Knee Osteoarthritis: A Systematic Review With Meta-Regression.
Synthesis in Musculoskeletal care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- FREquency of strength home exercises for knee osteoarthritis pain: Protocol for the FRESH non-inferiority randomised controlled trial.Osteoarthritis and cartilage open · 2026Article
- MULTIple or ONE home strengthening exercise(s) for knee osteoarthritis: Protocol for the MULTI-ONE randomised controlled trial.Osteoarthritis and cartilage open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether there is an association between total prescribed dosage of resistance exercise (volume, frequency, intensity, and duration) and change in pain and physical function in individuals with knee osteoarthritis (OA).
methodA systematic review with meta-regression was conducted, searching MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials until December 11, 2024. We included randomised controlled trials that compared resistance exercise for knee OA with non-exercise interventions. Meta-regression examined the association between total prescribed exercise dosage (volume × frequency × intensity × duration of the intervention) and standardised mean differences (SMDs) for change in pain and physical function. Covariates were included to attempt to reduce between-study heterogeneity.
resultsAnalysis of 14 trials (N = 1274) found no association between total prescribed resistance exercise dosage and changes in pain (slope coefficient: < 0.01 on a 0-100 scale [95% CI: < - 0.01 to < 0.01]; p = 0.18) or physical function (slope coefficient: < 0.01 on a 0-100 scale [95% CI: < - 0.01 to < 0.01]; p = 0.15). Heterogeneity was substantial (I
conclusionNo association was found between the total prescribed dosage of resistance exercise and changes in pain or function in individuals with knee OA. However, due to the limited number of trials, high heterogeneity, and overall low quality of studies, findings should be interpreted with caution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.