Evidence mapPaperPMID 40320793Full record

ArticleJournal of Alzheimer's disease : JAD2025

A critical examination of the relationship between cardiovascular health, cognition, and dementia risk.

Joshua L Gills, Omonigho M Bubu

Abstract readComment
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Joshua L GillsDepartment of Psychiatry, Aging Research in Sleep Equity and Dementia Prevention (ARISE-DP) Program, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-3321-4120
Omonigho M BubuDepartment of Psychiatry, Aging Research in Sleep Equity and Dementia Prevention (ARISE-DP) Program, NYU Grossman School of Medicine, New York, NY, USA.

Funding

Project 1U19AG024904 · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · 2025 to 2025
$29.2M
Treatment of OSA on sleep-dependent memory and blood biomarkers in blacksRF1AG083975 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OMONIGHO A MICHAEL Bubu, Korey Kam · 2023 to 2023
$2.5M
Using a Health Disparity Research Framework to examine mechanisms linking Obstructive Sleep Apnea with higher Alzheimer’s disease risk in older Blacks/African-AmericansR01AG082278 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2025 to 2025
$1.7M
Psychosocial CoreP30AG066512 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2025 to 2025
$1.3M
Postdoctoral Research Training in Alzheimer's Disease and Related Neurodegenerative DisordersT32AG052909 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2025 to 2025
$356k
The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic WhitesK23AG068534 · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2025 to 2025
$188k
NIA NIH HHS K23 AG068534NIA NIH HHS L30 AG064670NIA NIH HHS P30 AG066512NIA NIH HHS R01 AG082278NIA NIH HHS RF1 AG083975NIA NIH HHS T32 AG052909NIA NIH HHS U19 AG024904Wellcome Trust
6 · The paper itself

Abstract

Poor cardiovascular health is strongly linked to increased risk of cognitive impairment and Alzheimer's disease and related dementias. This commentary discusses Yang and associates' work on the associations between cardiovascular health in middle age, as defined by Life Essential 8 scores, and later digital cognitive performance and incident Alzheimer's disease. We examine the strengths and weaknesses of their study within the broader research context. We emphasize the potential significance of sleep and stress the need for longitudinal studies incorporating robust neuropsychiatric methodologies, advanced neuroimaging techniques, and diverse participant samples to enhance the reliability and generalizability of results.

Indexed as

Cardiovascular DiseasesCognitionDementiaCognitive DysfunctionHumansNeuropsychological TestsRisk FactorsAlzheimer's diseasecardiovascular risk factorscognitiondementia

Identifiers

PMID40320793
PMCPMC12788397

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.