ReviewThe Journal of physiology2026
The central benefit of physiologically induced ketogenic states.
Review in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Ketones not only act as metabolic fuel for the brain in periods of carbohydrate shortage, but also serve as signalling molecules that improve cognition. Ketogenic states can be induced peripherally by physiological interventions such as fasting and exercise, or ketogenic diets/exogenous supplementation. These interventions beneficially act on the brain through partially overlapping peripheral metabolic pathways. We focus on the role of peripheral organs such as the intestine, liver and skeletal muscle in mediating cognitive benefits in response to these interventions and discuss the prominent roles of the nuclear receptor peroxisome proliferator-activated receptor δ, which serves as a nutrient sensor guiding ketones to the brain, where they stimulate the multifunctional cognition-improving factor, brain-derived neurotrophic factor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.