Evidence map›Paper›PMID 40321038›Full record

ArticleRenal failure2025

Causal relationship between chronic kidney disease, renal function, and venous thromboembolism: a bidirectional Mendelian randomization study.

Rongping Yang, Shuanglan Xu, Qian Liu, Xifeng Zhang, Huilin He, Yue Xu, Linna Chen, Xiqian Xing, Jiao Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongping YangDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Shuanglan XuDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, Kunming, China.
Qian LiuDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xifeng ZhangDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Huilin HeDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yue XuDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Linna ChenDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiqian XingDepartment of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, Kunming, China.
Jiao YangDepartment of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) and impaired renal function have been implicated in venous thromboembolism (VTE), but their causal relationships remain uncertain. This study employs Mendelian randomization (MR) to elucidate the potential bidirectional causal effects between CKD, renal function biomarkers, and VTE.

methodsWe collated datasets from genome-wide association studies conducted among European individuals to perform MR analyses. The primary method utilized was the random-effect inverse variance-weighted (IVW) approach, with MR-Egger and the weighted median approaches employed as supplemental techniques. Several sensitivity studies were performed to assess the findings' robustness.

resultsWe identified a link between elevated serum creatinine levels and both VTE (OR: 1.14, 95% CI: 1.05-1.24,

conclusionsThis MR analysis provides evidence that elevated serum creatinine is associated with a higher risk of VTE and PE, while reduced eGFR may be a potential risk factor for VTE and its subtypes. These findings highlight the need for proactive monitoring and preventive strategies in individuals with impaired renal function. Further studies are warranted to confirm these associations and explore underlying mechanisms.

Indexed as

Renal Insufficiency, ChronicVenous ThromboembolismBiomarkersCreatinineGenome-Wide Association StudyGlomerular Filtration RateHumansMendelian Randomization AnalysisRisk FactorsBiomarkersCreatininecausal inferencechronic kidney diseasedeep vein thrombosisMendelian randomizationpulmonary embolismrenal functionVenous thromboembolism

Identifiers

PMID40321038
PMCPMC12054574

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.