Evidence map›Paper›PMID 40321081›Full record

ArticleThe Journal of physiology2025

Complexin gains effective access to the assembling SNAREs via its membrane-binding C-terminal domain.

Justine A Lottermoser, Haowen Liu, Jihong Bai, Zhitao Hu, Jeremy S Dittman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justine A LottermoserDepartment of Biochemistry, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-5251-4041
Haowen LiuDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Jihong BaiBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Zhitao HuDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong.
Jeremy S DittmanDepartment of Biochemistry, Weill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-3850-9078

Funding

Analysis of Synaptic Protein DynamicsR01NS116747 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Jeremy Samuel Dittman · 2020 to 2026
$2.6M
Investigating the coordinated functions of a dual Ca2+ sensor system in C. elegansR56NS128048 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICHMOND, JANET E · 2022 to 2022
$351k
Elucidating the Complexin C-terminal Domain Mechanism in Neurotransmission RegulationF31NS127534 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LOTTERMOSER, JUSTINE · 2022 to 2023
$76k
NINDS NIH HHS F31 NS127534NINDS NIH HHS R01 NS116747NINDS NIH HHS R56 NS128048
6 · The paper itself

Abstract

The conserved presynaptic SNARE-binding protein complexin (Cpx) promotes Ca

Indexed as

Adaptor Proteins, Vesicular TransportCaenorhabditis elegans ProteinsNerve Tissue ProteinsSNARE ProteinsAnimalsCaenorhabditis elegansCell MembraneProtein Domainsrab3 GTP-Binding ProteinsSynaptic TransmissionSynaptic VesiclesAdaptor Proteins, Vesicular TransportCaenorhabditis elegans Proteinscomplexin INerve Tissue Proteinsrab3 GTP-Binding ProteinsSNARE ProteinsC. eleganscomplexinRab3SNAREsynapsesynaptic vesicle

Identifiers

PMID40321081
PMCPMC12967288

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.