Evidence map›Paper›PMID 40322255›Full record

ArticleRSC advances2025

Enhanced immunoregulation in traumatic urethral stricture repair utilizing a glycyrrhizic acid-infused antiswelling biogel scaffold.

Zhihuan Zheng, Ziqiang Wu, Chao Li, Lei Zhou, Weibin Hou, Wei Xiong, Shuo Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhihuan ZhengDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.
Ziqiang WuDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.
Chao LiDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.
Lei ZhouDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.
Weibin HouDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.
Wei XiongDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.ORCID https://orcid.org/0009-0004-1524-7695
Shuo TanDepartment of Urology, The Third Xiangya Hospital of Central South University Changsha 410013 China xiongweixy3@csu.edu.cn tanshuo@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a prevalent complication following urinary system trauma, urethral stricture is characterized by progressive fibrosis and luminal narrowing often leading to recurrent dysuria and impaired renal function. Current treatments including surgical interventions face challenges such as high recurrence rates and secondary stenosis. Hydrogel-based drug delivery systems offer therapeutic potential but are limited by material swelling under urinary flow and insufficient modulation of inflammatory microenvironments. This study introduces an innovative anti-swelling carrageenan biogel scaffold (Car/Ga) functionalized with glycyrrhizic acid (Ga), a dual anti-inflammatory and immunoregulatory phytochemical. The Car matrix ensures structural stability in biological fluids by resisting swelling-induced obstruction while Ga targets trauma-induced inflammatory cascades through M1 macrophage polarization mitigation to reduce fibrotic progression.

Identifiers

PMID40322255
PMCPMC12046386

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.