Evidence map›Paper›PMID 40322467›Full record

ArticleOpen medicine (Warsaw, Poland)2025

Diverse electrophysiological demyelinating features in a late-onset glycogen storage disease type IIIa case.

Xiajun Zhou, Xingxing Zhong, Mingshi Gao, Dongyue Yue, Kai Qiao, Min Wang, Nan Zhi, Wenwei Cao, Lu Han, Jiahong Lu and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Open medicine (Warsaw, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiajun ZhouDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Xingxing ZhongDepartment of Neurology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Jiangsu, 225000, China.
Mingshi GaoDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Dongyue YueDepartment of Neurology, Jing'an District Center Hospital, Shanghai, 200040, China.
Kai QiaoDepartment of Neurology, and Huashan Rare Disease Center, Huashan Hospital, Fudan University, National Center for Neurological Disorders (NCND), Shanghai, 200040, China.
Min WangDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Nan ZhiDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Wenwei CaoDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Lu HanDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.
Jiahong LuDepartment of Neurology, and Huashan Rare Disease Center, Huashan Hospital, Fudan University, National Center for Neurological Disorders (NCND), Shanghai, 200040, China.
Wenhua ZhuDepartment of Neurology, and Huashan Rare Disease Center, Huashan Hospital, Fudan University, National Center for Neurological Disorders (NCND), Shanghai, 200040, China.
Chongbo ZhaoDepartment of Neurology, and Huashan Rare Disease Center, Huashan Hospital, Fudan University, National Center for Neurological Disorders (NCND), Shanghai, 200040, China.
Yangtai GuanDepartment of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China.ORCID https://orcid.org/0000-0003-0813-4073

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycogen storage disease type IIIa (GSD IIIa) is a rare etiology among patients with adult-onset myopathy, which is typically associated with axonopathy rather than demyelination. We report a genetically and pathologically confirmed case that exhibited prominent electrophysiological hallmarks of demyelination, including prolonged distal motor latency, temporal dispersion, prolonged F-waves, and conduction block. The presence of these diverse demyelinating characteristics in this context, excluding other factors, is infrequently reported, suggesting that glycogen accumulation may influence not only muscles but also potentially the myelin, thereby broadening our comprehension of this rare disease spectrum.

Indexed as

demyelinating diseaseselectrophysiologyglycogen debranching enzyme systemglycogen storage disease type III

Identifiers

PMID40322467
PMCPMC12048896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.