Evidence map›Paper›PMID 40322586›Full record

ArticleCurrent research in pharmacology and drug discovery2025

Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice.

Medha Satti, Kavita Prasad, Yash Patel, Demi Poulathas, Lawrence Walker, Esha Paghdal, Samuel Gunderson, Lei Yu

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In one paragraph

Article in Current research in pharmacology and drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Medha SattiDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Kavita PrasadDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.
Yash PatelDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Demi PoulathasDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Lawrence WalkerDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.
Esha PaghdalDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.
Samuel GundersonDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA.
Lei YuDepartment of Genetics, Rutgers University, Piscataway, NJ, 08854, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

U1 Adaptor is a novel gene-silencing technology, offering an innovative approach to target genes in the CNS for the treatment of diseases. Intrathecal delivery is a medically viable route of administration of CNS-bound nucleic acid drugs; therefore, it is important to investigate U1 Adaptor distribution after intrathecal drug delivery. We investigated the distribution patterns of U1 Adaptor upon intrathecal bolus administration in mice. It readily distributes to CNS tissues, including the lumbar and the cervical spinal cord, and the cerebellum. Over time, the U1 Adaptor also accumulates in the periphery, both in the liver and the kidneys, while plasma levels are undetectable. Our findings provide useful information for future in-depth pharmacokinetic modeling of U1 Adaptor distribution upon intrathecal administration.

Indexed as

Central nervous systemGene silencingIntrathecal administrationPharmacokineticsU1 adaptors

Identifiers

PMID40322586
PMCPMC12049946

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.