Evidence map›Paper›PMID 40322642›Full record

ArticleEuropean heart journal open2025

Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study.

Hosamadin S Assadi, Xiaodan Zhao, Gareth Matthews, Rui Li, Jordi Broncano Cabrero, Bahman Kasmai, Samer Alabed, Javier Royuela Del Val, Hilmar Spohr, Yashoda Gurung-Koney and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05114785 (PReserved Ejection Fraction Evaluation and Recognition by Cardiac Magnetic Resonance), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05114785 not yet recruitingnot on this map

PReserved Ejection Fraction Evaluation and Recognition by Cardiac Magnetic Resonance

TypeobservationalSponsorUniversity of East AngliaRan2022 to 2032Enrolled100ConditionsHeart Failure With Preserved Ejection Fraction, Heart DiseasesArmsMulti Parametric Cardiac Magnetic Resonance
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hosamadin S AssadiDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.ORCID https://orcid.org/0000-0002-6143-8095
Xiaodan ZhaoNational Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.ORCID https://orcid.org/0000-0003-1469-8027
Gareth MatthewsDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.ORCID https://orcid.org/0000-0001-8353-4806
Rui LiDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
Jordi Broncano CabreroCardiothoracic Imaging Unit, Hospital San Juan de Dios, Ressalta, HT Medica, Avenida el Brillante No. 36, 14012 Córdoba, Spain.
Bahman KasmaiDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
Samer AlabedDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK.ORCID https://orcid.org/0000-0002-9960-7587
Javier Royuela Del ValCardiothoracic Imaging Unit, Hospital San Juan de Dios, Ressalta, HT Medica, Avenida el Brillante No. 36, 14012 Córdoba, Spain.
Hilmar SpohrNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, Norfolk, UK.
Yashoda Gurung-KoneyNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, Norfolk, UK.
Nay AungBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, UK.ORCID https://orcid.org/0000-0001-5095-1611
Sunil NairNorfolk and Norwich University Hospitals NHS Foundation Trust, Norwich NR4 7UY, Norfolk, UK.
Andrew J SwiftNational Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Vassilios S VassiliouDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.
Liang ZhongNational Heart Research Institute Singapore, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Abdallah Al-MohammadDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2RX, UK.ORCID https://orcid.org/0000-0001-6517-8692
Rob J van der GeestDepartment of Radiology, Division of Image Processing, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.ORCID https://orcid.org/0000-0002-9084-5597
Peter P SwobodaDivision of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.ORCID https://orcid.org/0000-0001-7162-7079
Sven PleinDivision of Biomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.ORCID https://orcid.org/0000-0002-0997-4384
Pankaj GargDepartment of Cardiovascular and Metabolic Health, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, Norfolk, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Aims: Cardiac ageing involves a series of anatomical and physiological changes contributing to a decline in overall performance. Cardiac magnetic resonance (CMR) provides comprehensive structural and functional assessment for detecting age-related cardiovascular remodelling. We aimed to develop a fully automated CMR model to predict functional heart age. Methods and results: This international, multi-centre, retrospective observational study enrolled 191 healthy individuals with normal body mass index (BMI), free of metabolic, cardiovascular, and respiratory disease as the derivation cohort. Left atrial (LA) end-systolic volume and LA ejection fraction were selected for the final model. The model was validated on 366 patients with BMI >25 kg/m Conclusion: This study highlights the time course of structural and physiological changes in the heart during healthy and unhealthy ageing. We propose simple equations that should help communicate subtle changes in heart assessment with ageing. Registration: ClinicalTrials.gov: NCT05114785.

Indexed as

AgeingDiabetes mellitusHypertensionMagnetic resonance imaging (cine)Obesity

Identifiers

PMID40322642
PMCPMC12045662

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.