ArticlePhysiological reports2025
Effects of interval versus continuous exercise on cerebral vascular flow-mediated dilatation in young healthy males.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Cerebrovascular flow-mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations.Experimental physiology · 2026Review
- The Neurogenic Niche: Interactions Among Vessels, Glia, and Neural Stem Cells.Stem cells international · 2026Review
- Optimizing cerebrovascular endothelial health through shear stress modulation.Experimental physiology · 2025Review
- Effects of interval versus continuous exercise on cerebral vascular flow-mediated dilatation in young healthy males.Physiological reports · 2025Article
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Authors and funding
6 authors.
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Abstract
Aerobic exercise reduces the risk of cerebrovascular dysfunction. One proposed mechanism is exercise-induced increases in cerebral shear stress (SS) improving cerebral endothelial function. A recent report indicated that interval exercise (Int-Ex) induces greater cerebral SS than continuous exercise (Con-Ex); however, its effect on cerebral endothelial function remains unclear. We hypothesized that Int-Ex would enhance cerebral SS and, consequently, cerebral endothelial function more than Con-Ex. Fourteen healthy males (21 ± 0.6 years) completed 32 min of Int-Ex and work-equivalent Con-Ex on a semi-recumbent bike on separate days. Cerebrovascular flow-mediated dilatation (cFMD) was assessed before exercise (Pre), 15 min (Post-15) and 40 min post-exercise (Post-40). cFMD was defined as peak internal carotid artery vasodilatation (Δ% from baseline; Duplex ultrasound) in response to a 30-s hypercapnic exposure, raising end-tidal partial pressure of carbon dioxide by ~7 mmHg. Post-exercise cerebral SS was greater after Int-Ex versus Con-Ex (p = 0.002). Int-Ex evoked a ~37% increase in post-exercise cerebral SS compared to rest, with a negligible increase for Con-Ex. cFMD did not differ between Int-Ex and Con-Ex trials before exercise (Pre, 6.35 ± 3.89% vs. 5.54 ± 3.83%; p = 0.542) and remained unchanged post-exercise (Post-15, 7.20 ± 4.47% vs. 6.13 ± 4.08%; Post-40, 5.69 ± 3.86% vs. 6.94 ± 3.55%; p = 0.583). These results indicate that Int-Ex and Con-Ex have similar acute effects on cerebral endothelial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.