Evidence map›Paper›PMID 40323274›Full record

ArticleFuture medicinal chemistry2025

Larvicidal potential of Knoevenagel adducts against

Paloma G Abrantes, Poliana G Abrantes, Renata R Magalhães, Gildilayne M Silva, Natália F Sousa, Marcus T Scotti, Renan T Leite, Jheison M C Francelino, Fabíola C Nunes, Juliana A Vale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paloma G AbrantesDepartamento de Química, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Poliana G AbrantesDepartamento de Química, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Renata R MagalhãesDepartamento de Química, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Gildilayne M SilvaDepartamento de Química, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Natália F SousaLaboratório de Quimioinformática, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Marcus T ScottiLaboratório de Quimioinformática, Programa de Pós-graduação em Produtos Naturais e Sintéticos Bioativos, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.ORCID 0000-0003-4863-8057
Renan T LeiteDepartamento de Biologia Celular e Molecular, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Jheison M C FrancelinoDepartamento de Biologia Celular e Molecular, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Fabíola C NunesDepartamento de Biologia Celular e Molecular, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.
Juliana A ValeDepartamento de Química, Universidade Federal da Paraíba - UFPB, João Pessoa, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study investigated the larvicidal potential of Knoevenagel adducts against

methodsLarvicidal activity of Knoevenagel adducts (1a-l) was evaluated on fourth-stage

resultsCompounds 1c and 1g showed high larvicidal efficacy, with LC

conclusionsKnoevenagel adducts 1c and 1g are promising candidates for effective, selective, and environmentally friendly larvicides.

Indexed as

AedesInsecticidesAnimalsLarvaMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureStructure-Activity RelationshipInsecticidesAedes aegyptihemocyte compositionknoevenagel adductsLarvicidal activitynitric oxide productiontheoretical study

Identifiers

PMID40323274
PMCPMC12091929

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.