Evidence map›Paper›PMID 40323434›Full record

ArticleAntimicrobial agents and chemotherapy2025

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease.

Shiromani Jayawardhana, Francisco Olmo, Amanda Fortes Francisco, Archie A Khan, Michael D Lewis, Martin C Taylor, John M Kelly

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiromani JayawardhanaDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
Francisco OlmoDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0001-9314-0026
Amanda Fortes FranciscoDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3475-8130
Archie A KhanDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
Michael D LewisDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
Martin C TaylorDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.
John M KellyDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-4305-5258

Funding

Drugs for Neglected Diseases Initiative NAMedical Research CouncilMedical Research Council MR/R021430/1
6 · The paper itself

Abstract

Infections with

Indexed as

Chagas DiseaseGastrointestinal TractTriazolesTrypanocidal AgentsTrypanosoma cruziAnimalsChagas CardiomyopathyChronic DiseaseDisease Models, AnimalFemaleHeartMiceposaconazoleTriazolesTrypanocidal AgentsChagas diseaseintermittent treatmentpathologyposaconazoleTrypanosoma cruzi

Identifiers

PMID40323434
PMCPMC12135509

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.