Evidence map›Paper›PMID 40323488›Full record

SynthesisGeroScience2026

Effects of tetrahydroindenoindole supplementation on metabolism: A systematic review with meta-analysis of rodent-based studies.

Miguel Pérez-Rodríguez, Rafael A Casuso, Sandra Rodríguez-López, José A González-Reyes, José M Villalba

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cytochrome bBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miguel Pérez-RodríguezDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, and ceiA3 Campus of International Excellence in Agrifood, Córdoba, Spain. b42perom@uco.es.ORCID 0000-0003-1272-9213
Rafael A CasusoDepartment of Health Sciences, Universidad Loyola Andalucía, Córdoba, Spain.ORCID 0000-0002-4482-3186
Sandra Rodríguez-LópezLaboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5088-6458
José A González-ReyesDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, and ceiA3 Campus of International Excellence in Agrifood, Córdoba, Spain.ORCID 0000-0003-1918-5490
José M VillalbaDepartment of Cell Biology, Physiology and Immunology, University of Córdoba, and ceiA3 Campus of International Excellence in Agrifood, Córdoba, Spain. jmvillalba@uco.es.ORCID 0000-0001-8554-3802

Funding

Junta de Andalucía 1263735-RJunta de Andalucía P18-RT-4264Ministerio de Ciencia, Innovación y Universidades PID2021-126280OB-I00Ministerio de Ciencia, Innovación y Universidades RTI2018-100695-B-I00
6 · The paper itself

Abstract

Identifying novel compounds with therapeutic potential is a main area of interest in biomedical research. Tetrahydroindenoindole (THII) has emerged as a compound of interest due to both its antioxidant properties and its action as a pharmacological activator of the enzyme cytochrome b

Indexed as

Dietary SupplementsEnergy MetabolismIndolesAnimalsBlood GlucoseDiet, High-FatGlucose Tolerance TestMiceMitochondriaOxygen ConsumptionWeight GainBlood GlucoseIndolesMeta-analysisMetabolismMiceRodentsSystematic reviewTetrahydroindenoindole

Identifiers

PMID40323488
PMCPMC12972266

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.