ArticleInternational ophthalmology2025
Analysis of corneal mapping with anterior segment optical coherence tomography in severe obstructive sleep apnea syndrome patients.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeWe aimed to compare corneal thickness maps and ocular surface parameters with anterior segment optical coherence tomography (AS-OCT) between severe obstructive sleep apnea syndrome (OSAS) patients and healthy controls.
methodsThe study included patients with severe OSAS and healthy subjects. Ocular surface parameters (Schirmer, Tear break-up time (TBUT)), Oxford corneal staining score(OCSS), and Ocular surface disease index (OSDI) score were evaluated, and corneal thickness maps (total and epithelial) were obtained by AS-OCT in all participants.
resultsThe mean ages of the control (n:30) and patient (n:30) groups were 44.80 ± 6.5 and 48.3 ± 8.9 years, respectively (p:0.09). The mean Apnea hypopnea index (AHI) in the patient group was 64.53 ± 21.25, mean body mass index (BMI) was 31.33 ± 3.66. TBUT, Schirmer tests, OCSS and OSDI score were statistically significantly different between the groups (p < 0.001, p:0.037, p < 0.001, p < 0.001, respectively). There was no significant difference between the groups in the parameters in the corneal thickness maps using OCT.
conclusionOcular surface parameters may worsen in OSAS. There were no significant differences among groups in corneal epithelial thickness mapping using AS-OCT. Further research is needed to explore the long-term effects of the disease on corneal morphology.
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